| Identification | Back Directory | [Name]
N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE | [CAS]
143457-40-3 | [Synonyms]
TAPI-0
TAPI-O
TNF-ALPHA PROTEASE INHIBITOR-0
TNF-ALPHA PROTEASE INHIBITOR-O
TAPI-0 (TNF-± processing inhibitor-0)
HONHCOCH2CH(CH2-CH(CH3)2)CO-NAL-ALA-NH2
N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE
N-(R)-(2-(HYDROXYAMINOCARBONYL)METHYL)-4-METHYLPENTANOYL-L-3-(2'-NAPHTHYL) ALANYL-L-ALANINE AMIDE
N-[2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1- oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide
L-Alaninamide, N-[2-[2-(hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl- (9CI) | [Molecular Formula]
C24H32N4O5 | [MDL Number]
MFCD02684279 | [MOL File]
143457-40-3.mol | [Molecular Weight]
456.53 |
| Chemical Properties | Back Directory | [density ]
1.227±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
50% acetic acid: 1mg/mL
DMSO: 5mg/mL | [form ]
White powder. | [pka]
9.17±0.20(Predicted) | [color ]
white |
| Hazard Information | Back Directory | [Uses]
TAPI-0 is an inhibitor which blocks the maturation of cytokines, soluble cyokine receptors and other proteins that require the action of proteases. | [Biological Activity]
Cell permeable: no''Primary Target
TNF-α converting enzyme/ADAM17''Product does not compete with ATP.''Reversible: no''Target IC50: 100 nM against TACE (TNF-α converting enzyme/ADAM17) |
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| Company Name: |
Alabiotech Inc.
|
| Tel: |
001-619-354-5251 |
| Website: |
www.alabiotech-e.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|