| Identification | More | [Name]
HYDROQUINIDINE | [CAS]
1435-55-8 | [Synonyms]
DIHYDROQUINIDINE
HYDROQUINIDINE
(9s)-10,11-dihydro-6’-methoxycinchonan-9-ol
(9S)-10,11-Dihydro-6'-methoxycinchonan-9-ol
10,11-Dihydroquinidine
11-dihydro-6’-methoxy-1(9s)-cinchonan-9-o
6'-Methoxy-10,11-dihydrocinchonan-9-ol
Cinchonan-9-ol, 10,11-dihydro-6'-methoxy-, (9S)-
Hydroconchinine
Hydroconquinine
hydroquinidine anhydrous
Hydroxyquinidine
2-Hydroquinidine
Hydroquinidine (base and/or unspecified salts)
(1β,4β,7R,αS)-α-(6-Methoxy-4-quinolyl)-5β-ethyl-1-azabicyclo[2.2.2]octane-7-methanol
Hydroqninidine
(5-Ethyl-1-azabicyclo[2.2.2]octan-7-yl)-(6-methoxyquinolin-4-yl)methanol
(8a,9R)-10,11-Dihydro-6'-methoxycinchonan-9-ol | [EINECS(EC#)]
215-862-5 | [Molecular Formula]
C20H26N2O2 | [MDL Number]
MFCD00135599 | [Molecular Weight]
326.43 | [MOL File]
1435-55-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
169-170 °C(lit.)
| [alpha ]
226 º (C=2 IN ETOH) | [Boiling point ]
464.47°C (rough estimate) | [density ]
1.1117 (rough estimate) | [refractive index ]
1.6800 (estimate) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
chloroform: 0.1 g/mL, clear
| [form ]
A crystalline solid | [pka]
12.80±0.20(Predicted) | [optical activity]
[α]25/D +226°, c = 2 in ethanol | [Merck ]
13,4831 | [BRN ]
91441 | [InChIKey]
LJOQGZACKSYWCH-LHFMAAMQSA-N | [CAS DataBase Reference]
1435-55-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Hydroquinidine(1435-55-8) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S36:Wear suitable protective clothing . | [RIDADR ]
1544 | [WGK Germany ]
3
| [RTECS ]
MX3016000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Solid | [Uses]
antiarrhythmic, antimalarial | [Purification Methods]
It is slightly soluble in Et2O and H2O but readily soluble in hot EtOH. [Heidelberger & Jacobs J Am Chem Soc 41 826 1919, King J Chem Soc 523 1946.] The hydrochloride has m 273-274o, [] 26D +184o (c 1.3, MeOH) and is very soluble in MeOH and CHCl3, but less soluble in H2O, EtOH and still less soluble in dry Me2CO. [Kyker & Lewis J Biol Chem 157 707 1945, Emde Helv Chim Acta 15 557 1932, Beilstein 23/13 V 340.] |
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