| Identification | Back Directory | [Name]
3-(4-Chlorbutyl)-1H-indol-5-carbonitril | [CAS]
143612-79-7 | [Synonyms]
)-1H-indoL
143612-79-7
e-5-carbonitriL
Vilazodone INT 3
3-(4-Chlorobutyl)
InterMediate of Vilazodone
3-(4-chloro-butyl)-5-cyanoindole
3-(4- chlorideDing Ji)-5- cyanoindole
Vilazodone Hydrochloride Intermediate
3-(4-Chlorobutyl)indole-5-carbonitrile
3-(4-Chlorbutyl)-1H-indol-5-carbonitril
Chlorobutyl)indole-5-carbonitrile, 3-(4-
3-(4-Chlorbutyl)-1H-indol-5-carbonitrile
1H-Indole-5-carbonitrile, 3-(4-chlorobutyl)-
Vilazodone int-1 3-(4-Chlorobutyl)indole-5-carbonitrile
3-(4-Chlorbutyl)-1H-indol-5-carbonitril ISO 9001：2015 REACH
3-(4-Chlorobutyl)indole-5-carbonitrile
3-(4-chlorobutyl)-1H-indole-5-carbonitrile | [EINECS(EC#)]
801-938-0 | [Molecular Formula]
C13H13ClN2 | [MDL Number]
MFCD09833261 | [MOL File]
143612-79-7.mol | [Molecular Weight]
232.71 |
| Questions And Answer | Back Directory | [Synthesis]
3-(4-Chlorbutyl)-1H-indol-5-carbonitril can be obtained from 5-cyanoindole and 4-chlorobutyryl chloride via acylation and reduction reactions. First, using 5-cyanoindole and 4-chlorobutyryl chloride as raw materials, and dichloromethane as solvent, 5-cyanoindole was acylated by FC reaction under the catalysis of isobutylaluminum dichloride to obtain chlorobutyryl-substituted 5-cyanoindole (yield 82%). Then, again in dichloromethane, using isobutylaluminum dichloride as catalyst and sodium borohydride as reducing agent, the target compound 3-(4-Chlorbutyl)-1H-indol-5-carbonitril was successfully synthesized. 
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| Chemical Properties | Back Directory | [Melting point ]
99-100℃ | [Boiling point ]
448.1±35.0 °C(Predicted) | [density ]
1.22 | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [solubility ]
Chloroform (Slightly, Ethyl Acetate (Slightly) | [form ]
Solid | [pka]
15.93±0.30(Predicted) | [color ]
Off-White to Pale Beige | [InChI]
InChI=1S/C13H13ClN2/c14-6-2-1-3-11-9-16-13-5-4-10(8-15)7-12(11)13/h4-5,7,9,16H,1-3,6H2 | [InChIKey]
NJJWMEJWFYRORL-UHFFFAOYSA-N | [SMILES]
N1C2=C(C=C(C#N)C=C2)C(CCCCCl)=C1 | [CAS DataBase Reference]
143612-79-7 |
| Hazard Information | Back Directory | [Uses]
Reactant in the preparation of allosteric IGF-1R inhibitors, and dual 5-HT1A receptor agonists and serotonin reuptake inhibitors. |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
Jia Xing Isenchem Co.,Ltd
|
| Telephone: |
0573-85285100 18627885956 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList14265/0_EN.htm |
| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
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