| Identification | More | [Name]
Pyridaben | [CAS]
96489-71-3 | [Synonyms]
4-Chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-3(2H)-pyridazinone
ACIMITE SUPER
DINOMITE
NEXTER
ORACLEPOSEIDON
PYRAMITE
PYRIDABEN
Pyridazinone
SANMITE
2-tert.-Butyl-5-(4-tert.-butylbenzyl)-thio-4-chloro-3-dihydropyridazinone
2-tert-butyl-5-(4-tert-butyl-benzylthio)-4-chloropyridazin-3(2h)-one
3(2h)-pyridazinone,4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)ph
enyl)methyl)thio)-
nc129
nci129
PYRIDABEN PESTANAL
2-tert-Butyl-5-(4-tert-butylbenzylthio)-4-chloro-3[2H]-pyridazinone
pyridaben (bsi, draft e-iso)
4-Chloro-2-(1,1-dimethylethyl)-5-[[[4-(1,1-dimethy
3(2h)-pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)ph enyl)methyl) thio)- | [EINECS(EC#)]
405-700-3 | [Molecular Formula]
C19H25ClN2OS | [MDL Number]
MFCD00274601 | [Molecular Weight]
364.93 | [MOL File]
96489-71-3.mol |
| Chemical Properties | Back Directory | [Appearance]
White to tan crystalline solid or powder.
Faint vanilla odor. Commercial product is available as an
emulsifiable concentrate or wettable powder. | [Melting point ]
111-112° | [Boiling point ]
429.9±55.0 °C(Predicted) | [density ]
1.2 g/cm3 | [storage temp. ]
0-6°C | [solubility ]
Chloroform: Slightly Soluble | [form ]
neat | [pka]
-2.69±0.20(Predicted) | [Merck ]
13,8057 | [BRN ]
7933972 | [LogP]
6.370 | [CAS DataBase Reference]
96489-71-3(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyridaben(96489-71-3) | [EPA Substance Registry System]
96489-71-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T;N,N,T | [Risk Statements ]
R23/25:Toxic by inhalation and if swallowed .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3077 | [WGK Germany ]
3 | [RTECS ]
UR6149000 | [HazardClass ]
6.1(a) | [PackingGroup ]
II | [Hazardous Substances Data]
96489-71-3(Hazardous Substances Data) | [Toxicity]
LD50 in male, female rats, bobwhite quail, mallard ducks (mg/kg): 435, 358, >2250, >2500 orally (Hirata); LD50 in male, female rabbits (mg/kg): >2000, >2000 dermally (Hirata) |
| Hazard Information | Back Directory | [Potential Exposure]
Pyridaben is a pyridazinone insecti-
cide/acaricide/miticide used to control mites, whiteflies,
leafhoppers and psyllids on fruit trees, vegetables, orna-
mentals and other field crops. It is also used to control
pests in apple, grapes, pear, pistachio, stone fruits, and the
tree nuts group . | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. Give artificial respiration if
victim is not breathing. Do not use mouth-to-mouth
method if victim ingested or inhaled the substance; give
artificial respiration with the aid of a pocket mask
equipped with a one-way valve or other proper respiratory
medical device. Administer oxygen if breathing is diffi-
cult. Remove and isolate contaminated clothing and shoes.
In case of contact with substance, immediately flush skin
or eyes with running water for at least 20 minutes. For
minor skin contact, avoid spreading material on unaffected
skin. Keep victim warm and quiet. Effects of exposure
(inhalation, ingestion or skin contact) to substance may be
delayed. Ensure that medical personnel are aware of the
material(s) involved and take precautions to protect
themselves. | [Shipping]
UN2588 Pesticides, solid, toxic, Hazard Class:
6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. UN2902 Pesticides, liquid, toxic. UN2902
Pesticides, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels:
6.1-Poisonous materials, Technical Name Required. | [Incompatibilities]
Dust may form explosive mixture with
air. Incompatible with oxidizers (chlorates, nitrates, perox-
ides, permanganates, perchlorates, chlorine, bromine, fluo-
rine, etc.); contact may cause fires or explosions. Keep
away from alkaline materials, strong bases, strong acids,
oxoacids, epoxides. | [Chemical Properties]
Beige Solid | [Chemical Properties]
White to tan crystalline solid or powder.
Faint vanilla odor. Commercial product is available as an
emulsifiable concentrate or wettable powder. | [Waste Disposal]
It is the responsibility
of chemical waste generators to determine the toxicity and
physical properties and of a discarded chemical and to
properly identify its classification and certification as a haz-
ardous waste and to determine the disposal method. United
States Environmental Protection Agency guidelines for the
classification determination are listed in 40 CFR Parts
261.3. Additionally, waste generators must consult and
follow all regional, national, state and local hazardous
waste laws to ensure complete and accurate classification
and disposal methods. Follow recommendations for the
disposal of pesticides and pesticide containers. Containers must be disposed of properly by following package
label directions or by contacting your local or federal
environmental control agency, or by contacting your
regional EPA office. | [Definition]
ChEBI: Pyridaben is a pyridazinone, an organochlorine insecticide and an organochlorine acaricide. It has a role as a mitochondrial NADH:ubiquinone reductase inhibitor. | [Agricultural Uses]
Insecticide, Acaricide: Used to control mites, whiteflies, leafhoppers and psyllids on fruit trees, vegetables, ornamentals and other field crops. Pyramite is a selective contact miticide/insecticide that controls pests in apple, grapes, pear, pistachio, stone fruits, and the tree nuts group[83]. | [Trade name]
BAS®-300; NCI®-129; NESTER®; PYRAMITE®; SANMITE® |
| Questions And Answer | Back Directory | [Uses]
Pyridaben (NC-129, BAS 3001) is widely used as an acaricide with a long residual action and as an insecticide mainly against sucking insects. Trade names include Nexter, Oracle, Poseidon, Pyramite, Sanmite, and Starling.
| [Acute Toxicity]
Pyridaben shows moderate to low acute toxicity to mammals. The intraperitoneal LDso was 68 mg/kg in male rats (Igarashi and Sakamoto, 1994). The dermal toxicity is low but toxicity by the inhalation route is quite high. With sublethal doses in mice and rats, clinical signs included decreased food consumption, diarrhea, hypothermia, bradycardia, bradypnea, decreased spontaneous motor activity, abnormal gait, prostration, eye closing, amd piloerection. At near lethal or lethal doses (300 mg/kg or more) depression of the central nervous and cardiovascular systems were stronger, but no change occurred in motor functions, including coordination, muscle strength, and neuromuscular transmission, or in sensory functions. Early gastric lavage was effective in presenting poisoning in rats and loperamide was efficacious in reducing the diarrhea that occurred at low doses.
| [Carcinogenicity]
Pyridaben was not oncogenic in typical lifetime feeding studies in the rat and mouse. It is classified by the U.S. Environmental Protection Agency as a Group E compound (no evidence for carcinogenicity to humans).
| [Neurotoxicity]
Pyridaben caused only a low degree of acute neurotoxicity in a standard battery of neurobehavioral tests when given at a single oral dose of 200 mg/kg in males. Effects included piloerection, hypoactiviy, tremors, and lowered body temperature, but these were sporadic and transient. In a longer term (90 day) study in rats, no neurotoxicity or neuropathology was seen at oral doses up to 27 mg/kg/day, but plasma cholinesterase activity was reduced in females.
| [Environmental Fate and Toxicity]
Pyridaben has a low acute toxicity to birds, but it is extremely toxic to aquatic species. Its persistence in soil is relatively brief due to rapid microbial degradation (e.g., the half-life under aerobic conditions is reported to be less than 3 weeks). In natural water in the dark, the half-life is about 10 days, due mainly to microbial action since pyridaben is stable to hydrolysis over the pH range 5-9. The half-life including aqueous photolysis is about 30 min at pH 7 (Tomlin, 2000).
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