| Identification | Back Directory | [Name]
2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol | [CAS]
1436383-95-7 | [Synonyms]
BF738735
BF738735
(BF 738735
2-fluoro-4-(2-methyl-8-((3-(methylsulfonyl)benzyl)amino)imidazo[1,2-a]pyrazin-3-yl)phenol
Phenol, 2-fluoro-4-[2-methyl-8-[[[3-(methylsulfonyl)phenyl]methyl]amino]imidazo[1,2-a]pyrazin-3-yl]- | [Molecular Formula]
C21H19FN4O3S | [MOL File]
1436383-95-7.mol | [Molecular Weight]
426.46 |
| Chemical Properties | Back Directory | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 125 mg/mL (293.11 mM) | [form ]
Solid | [pka]
8.08±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BF738735 is a phosphatidylinositol 4-kinase III beta (PI4KIIIβ) inhibitor with an IC50 of 5.7 nM. | [Biological Activity]
Cell permeable: yes''Primary Target
PI4KIII&beta''Reversible: yes | [in vivo]
BF738735 is well tolerated by specimens with good plasma levels of the antiviral in circulation and a complete inhibition with 25 mg/kg and some inhibition with 5 mg/kg dose is observed[2]. | [IC 50]
PI4KIIIβ: 5.7 nM (IC50); PI4KIIIα: 1.7 μM (IC50) | [storage]
Store at -20°C | [References]
[1] van der Schaar HM, et al. A novel, broad-spectrum inhibitor of enterovirus replication that targets host cell factor phosphatidylinositol 4-kinase IIIβ. Antimicrob Agents Chemother. 2013 Oct;57(10):4971-81. DOI:10.1128/AAC.01175-13
[2] V Saarnio. Antiviral Molecules of Enteroviruses. 13.1.2017. |
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