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1443460-91-0

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1443460-91-0 Structure

1443460-91-0 Structure
IdentificationBack Directory
[Name]

HIV-RT inhibitor 1
[CAS]

1443460-91-0
[Synonyms]

HIV-RT inhibitor 1
GSK 2838232,GSK-2838232,Human immunodeficiency virus,GSK2838232,Inhibitor,HIV,inhibit
28-Norlup-18-en-21-one, 3-(3-carboxy-3-methyl-1-oxobutoxy)-17-[(1R)-2-[[(4-chlorophenyl)methyl][2-(dimethylamino)ethyl]amino]-1-hydroxyethyl]-, (3β)-
[Molecular Formula]

C48H73ClN2O6
[MDL Number]

MFCD30207861
[MOL File]

1443460-91-0.mol
[Molecular Weight]

809.57
Chemical PropertiesBack Directory
[Boiling point ]

817.1±65.0 °C(Predicted)
[density ]

1.17±0.1 g/cm3(Predicted)
[storage temp. ]

Store at 0-8 °C
[solubility ]

DMSO:25.0(Max Conc. mg/mL);30.88(Max Conc. mM)
[form ]

A crystalline solid
[pka]

4.48±0.28(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Description]

GSK2838232 is a second generation inhibitor of HIV-1 maturation (IC90 = 6.4 nM). It is active against a variety of HIV isolates resistant to bevirimat (PA-457; ).
[Uses]

GSK2838232 inhibit HIV reverse transcriptase activity across a broad panel of HIV-1 isolates, extracted from patent WO/2013090664A1, compound51.
[References]

[1] Hatcher Mark Andrew, et al. Preparation of betulin derivatives for the treatment of HIV. From PCT Int. Appl. (2013), WO 2013090664 A1 20130620.
Spectrum DetailBack Directory
[Spectrum Detail]

HIV-RT inhibitor 1(1443460-91-0)1HNMR
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