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14439-61-3

14439-61-3 Structure

14439-61-3 Structure
IdentificationBack Directory
[Name]

4'-CHLORODIAZEPAM
[CAS]

14439-61-3
[Synonyms]

RO 5-4864
Aids080743
Aids-080743
chlorodiazepam
4'-CHLORODIAZEPAM
4'-Chlorodiazepam
RO-54864, 4'-chlorodiazepam
4'-Chlorodiazepam >=98% (TLC)
TSPO Agonist, Ro5-4864 - CAS 14439-61-3 - Calbiochem
7-chloro-5(4-chlorophe)1,3-dihydro-1-me-1,4-benzodiaz.-2-on
1-Methyl-5-(4-chlorophenyl)-7-chloro-1H-1,4-benzodiazepine-2(3H)-one
1-Methyl-7-chloro-5-(4-chlorophenyl)-1H-1,4-benzodiazepine-2(3H)-one
7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
7-CHLORO-5-(4-CHLOROPHENYL)-1,3-DIHYDRO-1-METHYL-2H-1,4-BENZODIAZEPIN-2-ONE
7-chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl)-2h-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one
7-CHLORO-5-[4'-CHLOROPHENYL]-1,3-DIHYDRO-1-METHYL-2H-1,4-BENZODIAZEPIN-2-ONE
1-Methyl-5-(p-chlorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepine-2-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-
Ro5-4864, 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one
[Molecular Formula]

C16H12Cl2N2O
[MDL Number]

MFCD00043406
[MOL File]

14439-61-3.mol
[Molecular Weight]

319.19
Chemical PropertiesBack Directory
[Melting point ]

160-163 °C
[Boiling point ]

517.1±50.0 °C(Predicted)
[density ]

1.35±0.1 g/cm3(Predicted)
[storage temp. ]

+2C to +8C
[solubility ]

ethanol: 17 mg/mL
[form ]

Off-white powder
[pka]

3.08±0.10(Predicted)
[color ]

White to light yellow
[Water Solubility ]

2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
[BRN ]

685202
Safety DataBack Directory
[Hazard Codes ]

Xn
[Risk Statements ]

22
[Safety Statements ]

22-24/25
[RIDADR ]

2811
[WGK Germany ]

3
[RTECS ]

DF0500000
[F ]

10
[HazardClass ]

6.1(b)
[PackingGroup ]

III
[Hazardous Substances Data]

14439-61-3(Hazardous Substances Data)
Hazard InformationBack Directory
[Uses]

4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines.
[Biochem/physiol Actions]

4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies.
Tags:14439-61-3 Related Product Information
439-14-5 13280-16-5 1013-88-3 2898-08-0

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