| Identification | Back Directory | [Name]
4'-CHLORODIAZEPAM | [CAS]
14439-61-3 | [Synonyms]
RO 5-4864
Aids080743
Aids-080743
chlorodiazepam
4'-CHLORODIAZEPAM
4'-Chlorodiazepam
RO-54864, 4'-chlorodiazepam
4'-Chlorodiazepam >=98% (TLC)
TSPO Agonist, Ro5-4864 - CAS 14439-61-3 - Calbiochem
7-chloro-5(4-chlorophe)1,3-dihydro-1-me-1,4-benzodiaz.-2-on
1-Methyl-5-(4-chlorophenyl)-7-chloro-1H-1,4-benzodiazepine-2(3H)-one
1-Methyl-7-chloro-5-(4-chlorophenyl)-1H-1,4-benzodiazepine-2(3H)-one
7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
7-chloro-5-(p-chlorophenyl)-1,3-dihydro-1-methyl-2h-4-benzodiazepin-2-one
7-CHLORO-5-(4-CHLOROPHENYL)-1,3-DIHYDRO-1-METHYL-2H-1,4-BENZODIAZEPIN-2-ONE
7-chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl)-2h-1,4-benzodiazepin-2-one
7-Chloro-1,3-dihydro-1-methyl-5-(4-chlorophenyl)-2H-1,4-benzodiazepin-2-one
7-CHLORO-5-[4'-CHLOROPHENYL]-1,3-DIHYDRO-1-METHYL-2H-1,4-BENZODIAZEPIN-2-ONE
1-Methyl-5-(p-chlorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepine-2-one
2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-
Ro5-4864, 7-Chloro-5-(4-chlorophenyl)-1,3-dihydro-1-methyl-2H-1,4-benzodiazepin-2-one | [Molecular Formula]
C16H12Cl2N2O | [MDL Number]
MFCD00043406 | [MOL File]
14439-61-3.mol | [Molecular Weight]
319.19 |
| Chemical Properties | Back Directory | [Melting point ]
160-163 °C | [Boiling point ]
517.1±50.0 °C(Predicted) | [density ]
1.35±0.1 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
ethanol: 17 mg/mL | [form ]
Off-white powder | [pka]
3.08±0.10(Predicted) | [color ]
White to light yellow | [Water Solubility ]
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble | [BRN ]
685202 | [InChI]
1S/C16H12Cl2N2O/c1-20-14-7-6-12(18)8-13(14)16(19-9-15(20)21)10-2-4-11(17)5-3-10/h2-8H,9H2,1H3 | [InChIKey]
PUMYFTJOWAJIKF-UHFFFAOYSA-N | [SMILES]
O=C1CN=C(C2=CC=C(Cl)C=C2)C3=CC(Cl)=CC=C3N1C |
| Hazard Information | Back Directory | [Uses]
4′-Chlorodiazepam has been used as a translocator protein ligand in mitochondrial functional studies. It has also been used to investigate its protective effects on glucose deprived T98G astrocyte cell lines. | [Biochem/physiol Actions]
4′-Chlorodiazepam (Ro5-4864) is a potent selective ligand for the mitochondrial translocator protein 18kDa (TSPO), formerly known as the peripheral benzodiazepine receptor (PBR). Ro5-4864 does not bind to GABA(A) receptors and lacks typical benzodiazepine effects, but has been found to be neuroprotective in several studies. |
|
|