| Identification | Back Directory | [Name]
(1S)-1α-(3,5-Dimethoxy-4-hydroxyphenyl)-6,8-dimethoxy-7-hydroxy-1,2,3,4-tetrahydronaphthalene-2β,3α-dimethanol | [CAS]
14464-90-5 | [Synonyms]
Lyoniresil
Lyoniresinol
(+)-Lyoniresinol
(1S)-1α-(3,5-Dimethoxy-4-hydroxyphenyl)-6,8-dimethoxy-7-hydroxy-tetralin-2β,3α-dimethanol
(2R)-4β-(4-Hydroxy-3,5-dimethoxyphenyl)-6-hydroxy-5,7-dimethoxy-1,2,3,4-tetrahydronaphthalene-2β,3α-dimethanol
(1S)-1α-(3,5-Dimethoxy-4-hydroxyphenyl)-6,8-dimethoxy-7-hydroxy-1,2,3,4-tetrahydronaphthalene-2β,3α-dimethanol
[1S,(+)]-1,2,3,4-Tetrahydro-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-6,8-dimethoxy-2β,3α-naphthalenedimethanol
2,3-Naphthalenedimethanol, 1,2,3,4-tetrahydro-7-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-6,8-dimethoxy-, (1S,2R,3R)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C22H28O8 | [MDL Number]
MFCD20260732 | [MOL File]
14464-90-5.mol | [Molecular Weight]
420.45 |
| Chemical Properties | Back Directory | [Melting point ]
170.7-171.0 °C | [Boiling point ]
617.6±55.0 °C(Predicted) | [density ]
1.272±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
10.05±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Lyoniresinol is a lignan isolated from the Tarenna attenuata with antioxidant activities. Lyoniresinol has radical scavenging activities against DPPH with an IC50 of 82.4 μM[1]. | [Definition]
ChEBI: (+)-lyoniresinol is a lignan that is tetralin substituted by a 4-hydroxy-3,5-dimethoxy group at position 4, hydroxymethyl groups at positions 2 and 3, methoxy groups at positions 5 and 7 and a hydroxy group at position 6. Isolated from Machilus robusta and Sinocalamus affinis, it exhibits antineoplastic activity. It has a role as a metabolite and an antineoplastic agent. It is a dimethoxybenzene, a lignan, a primary alcohol, a polyphenol and a member of tetralins. | [target]
ERK | [References]
[1] Xian-Wen Yang, et al. Tarennanosides A-H, eight new lignan glucosides from Tarenna attenuata and their protective effect on H2O2-induced impairment in PC12 cells. Chem Biodivers. 2009 Apr;6(4):540-50. DOI:10.1002/cbdv.200800022 |
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