| Identification | Back Directory | [Name]
Azido-PEG5-CH2CO2t-butyl ester | [CAS]
1448451-72-6 | [Synonyms]
Azido-PEG5-Boc N3-PEG5-CH2COOtBu Reaxys ID: 23811246 AZIDO-PEG5-CH2CO2TBU Azido-PEG5-CH2CO2t-butyl ester | [Molecular Formula]
C16H31N3O7 | [MDL Number]
MFCD27977490 | [MOL File]
1448451-72-6.mol | [Molecular Weight]
377.44 |
| Hazard Information | Back Directory | [Description]
Azido-PEG5-CH2CO2-t-Bu consist of an azide group(N3) and a t-butyl ester.The azide group can react with alkyne, BCN, DBCO via Click Chemistry. The t-butyl protected carboxyl group can be deprotected under acidic conditions. PEG spacer increases solubility in aqueous media. | [Uses]
Azido-PEG5-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG5-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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