| Identification | Back Directory | [Name]
AZ82 | [CAS]
1449578-65-7 | [Synonyms]
AZ82
KIFC1 inhibitor AZ82
KIFC1 Inhibitor, AZ82 - CAS 1449578-65-7 - Calbiochem
3-Pyridinepropanamide, α-[[(5-methyl-4-propyl-2-thienyl)carbonyl]amino]-N-(3R)-3-pyrrolidinyl-6-[3-(trifluoromethoxy)phenyl]-, (αR)-
5-methyl-N-[(2R)-1-oxo-1-[[(3R)-pyrrolidin-3-yl]amino]-3-[6-[3-(trifluoromethoxy)phenyl]pyridin-3-yl]propan-2-yl]-4-propylthiophene-2-carboxamide | [Molecular Formula]
C28H31F3N4O3S | [MDL Number]
MFCD28386163 | [MOL File]
1449578-65-7.mol | [Molecular Weight]
560.63 |
| Chemical Properties | Back Directory | [Boiling point ]
707.9±60.0 °C(Predicted) | [density ]
1.32±0.1 g/cm3(Predicted) | [storage temp. ]
+2C to +8C | [solubility ]
DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | [form ]
Yellow film | [pka]
13.25±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
AZ82 is a selective kinesin-like protein KIFC1 (HSET/KIFC1) inhibitor, with a Ki of 43 nM and an IC50 of 300 nM for KIFC1. | [Biological Activity]
Cell permeable: yes''Primary Target
MT/KIFC1''Reversible: yes | [IC 50]
HSET/KIFC1: 300 nM (IC50); HSET/KIFC1: 43 nM (Ki) | [References]
[1] Godinho SA, et al. Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci. 2014 Sep 5;369(1650). DOI:10.1098/rstb.2013.0467
[2] Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1. Wu J, et al. ACS Chem Biol. 2013 Oct 18;8(10):2201-8. DOI:10.1021/cb400186w |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
cjbscvictory
|
| Tel: |
13348960310 |
| Website: |
https://www.weikeqi-biotech.com/ |
| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|