| Identification | Back Directory | [Name]
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid | [CAS]
145-63-1 | [Synonyms]
Naganil
Fourneau
Suramine
Naphuride
Farma 939
Aids000067
Aids-000067
129-46-4(Hexasodium salt)
8,8-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
8,8'-[Carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonyl-imino]]bis-1,3,5-naphthalenetrisulfonic acid
8,8'-[carbonylbis[imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino]]bisnaphthalene-1,3,5-trisulphonic acid
1,3,5-Naphthalenetrisulfonic acid, 8,8'-[carbonylbis[iMino-3,1-phenylenecarbonyliMino(4-Methyl-3,1-phenylene)carbonyliMino]]bis-
8,8'-((3,3'-((3,3'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(4-Methylbenzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonic acid) | [EINECS(EC#)]
205-658-4 | [Molecular Formula]
C51H40N6O23S6 | [MDL Number]
MFCD00242612 | [MOL File]
145-63-1.mol | [Molecular Weight]
1297.28 |
| Chemical Properties | Back Directory | [Melting point ]
128 °C(Solv: ethyl ether (60-29-7)) | [density ]
1.2629 (rough estimate) | [refractive index ]
1.7770 (estimate) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
-1.35±0.40(Predicted) | [color ]
Pinkish-white, hygroscopic powder | [EPA Substance Registry System]
Suramin (145-63-1) |
| Hazard Information | Back Directory | [Definition]
ChEBI: Suramin is a member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years. It has a role as a ryanodine receptor agonist, a GABA-gated chloride channel antagonist, a GABA antagonist, an apoptosis inhibitor, an antineoplastic agent, an angiogenesis inhibitor, a purinergic receptor P2 antagonist, an EC 2.7.11.13 (protein kinase C) inhibitor, an antinematodal drug and a trypanocidal drug. It is a member of phenylureas, a secondary carboxamide and a naphthalenesulfonic acid. It is functionally related to a naphthalene-1,3,5-trisulfonic acid. It is a conjugate acid of a suramin(6-). | [Safety Profile]
Moderately toxic by intravenousroute. Human systemic effects by intravenous route: eyeeffects. An experimental teratogen. Other experimentalreproductive effects. When heated to decomposition itemits very toxic fumes of SOx and NOx. |
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| Company Name: |
PT CHEM GROUP LIMITED
|
| Telephone: |
+86-85511178; +86-85511178 |
| Website: |
https://www.chemicalbook.com/manufacturer/henan-lihao-chem-plant-25020/ |
| Company Name: |
ENBRIDGE PHARMTECH CO., LTD.
|
| Telephone: |
+8613812269233 |
| Website: |
https://www.chemicalbook.com/manufacturer/enbridge-pharmtech-240/ |
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