| Identification | Back Directory | [Name]
KALIOTOXIN | [CAS]
145199-73-1 | [Synonyms]
KTX
KALIOTOXIN
KALIOTOXIN (KTX)
KALIOTOXIN USP/EP/BP
KALIOTOXIN SYNTHETIC >93% FROM VENOM OF THE MOR
KALIOTOXIN (1-37) (SCORPION, ANDROCTONUS MAURETANICUS MAURETANICUS)
GLY-VAL-GLU-ILE-ASN-VAL-LYS-CYS-SER-GLY-SER-PRO-GLN-CYS-LEU-LYS-PRO-CYS-LYS-ASP-ALA-GLY-MET-ARG-PHE-GLY-LYS-CYS-MET-ASN-ARG-LYS-CYS-HIS-CYS-THR-PRO-LYS
H-GLY-VAL-GLU-ILE-ASN-VAL-LYS-CYS-SER-GLY-SER-PRO-GLN-CYS-LEU-LYS-PRO-CYS-LYS-ASP-ALA-GLY-MET-ARG-PHE-GLY-LYS-CYS-MET-ASN-ARG-LYS-CYS-HIS-CYS-THR-PRO-LYS-OH | [Molecular Formula]
C171H283N55O49S8 | [MDL Number]
MFCD00212233 | [MOL File]
145199-73-1.mol | [Molecular Weight]
4149.94 |
| Chemical Properties | Back Directory | [storage temp. ]
-15°C | [form ]
Lyophilized. | [Water Solubility ]
Soluble to 2 mg/ml in water | [Sequence]
Gly-Val-Glu-Ile-Asn-Val-Lys-Cys-Ser-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Met-Asn-Arg-Lys-Cys-His-Cys-Thr-Pro-Lys (Disulfide bridge: Cys8-Cys28;Cys14-Cys33;Cys18-Cys35) |
| Hazard Information | Back Directory | [Uses]
Kaliotoxin is a highly selective, high conductance Ca2+-activated Kv1.1 and Kv1.3 blocker. | [in vivo]
Kaliotoxin facilitates cognitive processes by the blockage of Kv1.1 or Kv1.3 channels[2]. | Animal Model: | Male Sprague–Dawley rats (280–300 g)[2] | | Dosage: | 10 ng | | Administration: | Intracerebroventricular injection | | Result: | Improved learning but not information consolidation.
Increased the long-term retrieval of an odour-reward association.
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