ChemicalBook--->CAS DataBase List--->145333-02-4

145333-02-4

Request For Quotation
145333-02-4 Structure

145333-02-4 Structure
IdentificationBack Directory
[Name]

BisindolylMaleiMide XI Hydrochloride
[CAS]

145333-02-4
[Synonyms]

Bisindoylmaleimide XI
Ro-32-0432 - CAS 145333-02-4 - Calbiochem
3-(8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-4-(1-methylindol-3-yl)maleimide hydrochloride
3-[8-[(dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methylindol-3-yl)pyrrole-2,5-dione:hydrochloride
3-[8-[(Dimethylamino)methyl]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride
[Molecular Formula]

C28H29ClN4O2
[MOL File]

145333-02-4.mol
[Molecular Weight]

489.008
Chemical PropertiesBack Directory
[storage temp. ]

-20°C
[solubility ]

DMSO: soluble5mg/mL
[form ]

solid
[color ]

orange
[InChIKey]

WMVQGKBSNAIMHI-UHFFFAOYSA-N
[SMILES]

Cl.[n]21c3c(cc2CC(CC1)CN(C)C)ccc(c3)C4=C(C(=O)NC4=O)c5c6c([n](c5)C)cccc6
Safety DataBack Directory
[WGK Germany ]

3
[Storage Class]

11 - Combustible Solids
Hazard InformationBack Directory
[Uses]

Bisindolylmaleimide XI is a potent and selective cell-permeable protein kinase C (PKC) inhibitor. Studies reveal that inhibition of PKCα by Bisindolylmaleimide XI and other similar PKC inhibitors has been associated with enhanced cardiac contractility and protection from heart failure. Bisindolylmaleimide XI has been shown to prevent T-cell activation and proliferation associated with chronic inflammatory responses in vivo.
[Biological Activity]

Cell permeable: yes''Primary Target
PKCα''Product does not compete with ATP.''Reversible: no''Target IC50: 9 nM28 nM108 nMagainst PKCαPKCβIand PKCεrespectively
[in vivo]

Oral administration of Bisindolylmaleimide XI hydrochloride inhibits subsequent phorbol ester-induced edema in ratss. Induction of more physiologically T-cell driven responses such as host vs. graft responses and the secondary paw swelling in adjuvant-induced arthritis are also inhibited by Bisindolylmaleimide XI hydrochloride[2].

[IC 50]

PKC-α: 9 nM (IC50); PKC-βI: 28 nM (IC50); PKC-βII: 31 nM (IC50); PKC-γ: 37 nM (IC50); PKC-ε: 108 nM (IC50)
[storage]

Store at -20°C
145333-02-4 suppliers list
Company Name: J & K SCIENTIFIC LTD.  
Telephone: 18210857532 18210857532
Website: https://www.jkchemical.com
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Telephone: 021-65675885 18964387627
Website: http://www.efebio.com
Company Name: Dezhou LonWel Pharmaceutical Technology Co., Ltd.  
Telephone: 13761310616
Website: https://www.chemicalbook.com/ShowSupplierProductsList20080/0_EN.htm
Company Name: Shenzhen Polymeri Biochemical Technology Co., Ltd.  
Telephone: +86-400-002-6226
Website: https://www.rrkchem.com
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  
Telephone: 18818260767
Website: http://www.chemegen.com
Company Name: Energy Chemical  
Telephone: 400-0056266
Website: www.energy-chemical.com
Company Name: TargetMol Chemicals Inc.  
Telephone: 4008200310 15002144251
Website: https://www.targetmol.cn/
Company Name: Shanghai Tachizaki Biomedical Research Center  
Telephone: 18014399201
Website: http://www.chemlab-tachizaki.com/
Company Name: RD International Technology Co., Limited  
Telephone: 18024082417
Website: www.ruidiresearch.com
Tags:145333-02-4 Related Product Information
176504-36-2 138516-31-1 145317-11-9 119139-23-0 138489-18-6