| Identification | Back Directory | [Name]
RO-31-8220 | [CAS]
138489-18-6 | [Synonyms]
CS-1132
RO-31-8220
Ro31-8220MsOH
Ro 31-8220 Mesylat
Ro 31-8220/Ro318220
RO-31-8220 USP/EP/BP
BisindolylMaleiMide IX Mesylate
BISINDOLYLMALEIMIDE IX, METHANESULFONATE
Ro-31-8220 - CAS 138489-18-6 - Calbiochem
Bisindolylmaleimide IX (Ro 31-8220 Mesylate)
BISINDOLYLMALEIMIDE IX METHANESULPHONATE SALT
BisindolylMaleiMide IX . Methansulfonate [Ro 31-8220]
RO 31-8220 METHANESULFONATE; BISINDOLYLMALEIMIDE IX MESYLATE;RO318220
3-[1-[3-(AMIDINOTHIO)PROPYL-1H-INDOL-3-YL]-3-(1-METHYL-1H-INDOL-3-YL)MALEIMIDE
3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate
Carbamimidothioic acid, 3-[3-[2,5-dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl ester, methanesulfonate (1:1) | [Molecular Formula]
C25H23N5O2S | [MDL Number]
MFCD00236436 | [MOL File]
138489-18-6.mol | [Molecular Weight]
457.55 |
| Questions And Answer | Back Directory | [Description]
Ro 31-8220 mesylate is a potent PKC inhibitor, inhibits PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC with IC50 values of 5, 24, 14, 27, 24 and 23 nM, also inhibits MAPKAP -K1b, MSK1, S6K1 and GSK3β with IC50 of 3, 8, 15, 38 nM. |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
DMSO:52.77(Max Conc. mg/mL);95.31(Max Conc. mM)
DMF:25.0(Max Conc. mg/mL);45.15(Max Conc. mM)
DMF:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.18(Max Conc. mM)
Ethanol:2.77(Max Conc. mg/mL);5.0(Max Conc. mM) | [form ]
Red solid | [color ]
Red | [biological source]
synthetic (organic) | [Water Solubility ]
water: 1mg/mL
DMSO: 100mg/mL | [InChIKey]
SAWVGDJBSPLRRB-UHFFFAOYSA-N | [SMILES]
CS(O)(=O)=O.Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCSC(N)=N)c4ccccc34)c5ccccc15 |
| Hazard Information | Back Directory | [Uses]
Ro 31-8220 Mesylate is a protein kinase C (PKC) inhibitor. | [General Description]
Ro 31-8220 is a bisindolylmaleimide derivative of staurosporine. Ro 31-8220 blocks MAP kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression and stimulates Jun N-terminal Kinase (JNK1). It has immunosuppressive properties. | [Biochem/physiol Actions]
Inhibitor of GRK-5 (G protein-coupled receptor kinase); PKC (protein kinase C); MAPKAP kinase 1β and p70 S6 kinase. | [in vivo]
Ro 31-8220 (6 mg/kg/d, s.c.) is well tolerated, and has half-life of 5.7 hours in mice. Ro 31-8220-treated MLP?/? mice show a dramatic rescue in fractional shortening after treatment for 6 weeks, but the WT mice shows no change[4]. | [IC 50]
PKC-α: 5 nM (IC50); PKC-βII: 14 nM (IC50); PKC-βI: 24 nM (IC50); PKC-ε: 24 nM (IC50); PKC-γ: 27 nM (IC50); Rat Brain PKC: 23 nM (IC50); MAPKAP-K1b: 3 nM (IC50); MSK1: 8 nM (IC50); S6K1: 15 nM (IC50); GSK3β: 38 nM (IC50) | [storage]
+4°C |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
D&C Chemicals
|
| Telephone: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|