| Identification | Back Directory | [Name]
PU-WS13 | [CAS]
1454619-14-7 | [Synonyms]
PU-WS13
CS-1689
CS-2047
PU WS13;PUWS13
8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine
8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine
6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)- | [Molecular Formula]
C17H20Cl2N6S | [MDL Number]
MFCD28156414 | [MOL File]
1454619-14-7.mol | [Molecular Weight]
411.35 |
| Chemical Properties | Back Directory | [Boiling point ]
617.4±65.0 °C(Predicted) | [density ]
1.47±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMF: 30 mg/mL,DMSO: 30 mg/mL,DMSO:PBS(pH7.2) (1:1): 0.5 mg/mL,Ethanol: 25 mg/mL | [form ]
Powder | [pka]
10.15±0.29(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Description]
PU-WS13 is an inhibitor of the heat shock protein family member and chaperone protein glucose-regulated protein 94 (GRP94; IC50 = 0.22 μM). It is selective for GRP94 over the chaperones Hsp90α, Hsp90β, and TRAP1 (IC50s = 27.3, 41.8, and 7.3 μM, respectively). PU-WS13 (0.5, 2.5, and 12.5 μM) induces apoptosis without increasing Hsp70 protein levels in HER2-overexpressing SK-BR-3, BT474, and MDA-MB-361 breast cancer cells. It also induces apoptosis and necrosis in multiple myeloma cells but does not induces cell death in pre-B leukemic cells. | [Uses]
PU-WS13 is a pharmaceutical agent used in the preparation go paralog=selective HSP90 inhibitors used in anti-tumor treatments. | [IC 50]
GRP94: 0.22 μM (EC50); HSP90α: 27.3 μM (EC50); HSP90β: 41.8 μM (EC50); TRAP-1: 7.3 μM (EC50) | [storage]
Store at -20°C |
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