1454619-14-7
1454619-14-7 结构式
基本信息
6-氨基-8-[(3,5-二氯苯基)硫基]-N-异丙基-9H-嘌呤-9-丙胺
CS-2047
CS-1689
PU WS13
PUWS13
8-((3,5-dichlorophenyl)thio)-9-(3-(isopropylamino)propyl)-9H-purin-6-amine
8-(3,5-dichlorophenyl)sulfanyl-9-[3-(propan-2-ylamino)propyl]purin-6-amine
6-Amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine
9H-Purine-9-propanamine, 6-amino-8-[(3,5-dichlorophenyl)thio]-N-(1-methylethyl)-
物理化学性质
| 报价日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
| 2024/04/30 | HY-18680 | PU-WS13 | 1454619-14-7 | 5mg | 900元 |
| 2024/04/30 | HY-18680 | PU-WS13 | 1454619-14-7 | 10mg | 1430元 |
| 2024/04/30 | HY-18680 | PU-WS13 | 1454619-14-7 | 50mg | 6160元 |
常见问题列表
|
GRP94 0.22 μM (EC 50 ) |
HSP90α 27.3 μM (EC 50 ) |
HSP90β 41.8 μM (EC 50 ) |
TRAP-1 7.3 μM (EC 50 ) |
PU-WS13 is a Grp94 inhibitor, with an EC 50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC 50 s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells.