| Identification | More | [Name]
3-FLUORO-2-IODOPYRIDINE | [CAS]
146141-04-0 | [Synonyms]
3-FLUORO-2-IODOPYRIDINE
2-IODO-3-FLUOROPYRIDINE | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C5H3FIN | [MDL Number]
MFCD03095288 | [Molecular Weight]
222.99 | [MOL File]
146141-04-0.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-fluoro-2-iodopyridine from 2-chloro-3-fluoropyridine: To a solution of 2-chloro-3-fluoropyridine (400 mg, 3 mmol) in dioxane (6 mL, 0.5 M) was added chlorotrimethylsilane (652 mg, 6 mmol) and sodium iodide (2.20 g, 15 mmol) in one go. The reaction mixture was stirred at 80 °C overnight. After completion of the reaction, the reaction mixture was concentrated to give 660 mg of 3-fluoro-2-iodopyridine (yield: 98%), the product was a yellow oil, which was directly used in the next reaction without further purification. | [References]
[1] Patent: WO2005/123703, 2005, A2. Location in patent: Page/Page column 223 |
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