| Identification | Back Directory | [Name]
Soravtansine | [CAS]
1461704-01-7 | [Synonyms]
Soravtansine
Sulfo-PDBA-DM4
Sulfo-PDBA-DM4, 98%，
Maytansine, N2'-[4-[(3-carboxy-3-sulfopropyl)dithio]-4-methyl-1-oxopentyl]-N2'-deacetyl- | [Molecular Formula]
C42H60ClN3O15S3 | [MDL Number]
MFCD32263224 | [MOL File]
1461704-01-7.mol | [Molecular Weight]
978.58 |
| Hazard Information | Back Directory | [Uses]
Sulfo-PDBA-DM4 is a agent-linker conjugate composed of a potent a tubulin inhibitor DM4 and a linker Sulfo-PDBA to make antibody agent conjugate (ADC). Sulfo-PDBA is a gluthatione cleavable linker. | [IC 50]
Maytansinoids | [References]
[1] Sun X, et al. Effects of Drug-Antibody Ratio on Pharmacokinetics, Biodistribution, Efficacy, and Tolerability of Antibody-Maytansinoid Conjugates. Bioconjug Chem. 2017 May 17;28(5):1371-1381. DOI:10.1021/acs.bioconjchem.7b00062 |
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| Company Name: |
Twochem Co.Ltd
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| Tel: |
021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
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