| Identification | Back Directory | [Name]
Deruxtecan analog | [CAS]
1599440-13-7 | [Synonyms]
Deruxtecan
MC-GGFG-Exetecan
Deruxtecan analog
Glycinamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]glycylglycyl-L-phenylalanyl-N-[[2-[[(1S,9S)-9-ethyl-5-fluoro-2,3,9,10,13,15-hexahydro-9-hydroxy-4-methyl-10,13-dioxo-1H,12H-benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinolin-1-yl]amino]-2-oxoethoxy]methyl]- | [Molecular Formula]
C52H56FN9O13 | [MDL Number]
MFCD31657445 | [MOL File]
1599440-13-7.mol | [Molecular Weight]
1034.05 |
| Chemical Properties | Back Directory | [Boiling point ]
1491.1±65.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [solubility ]
DMSO:67.5(Max Conc. mg/mL);65.28(Max Conc. mM) | [form ]
Solid | [pka]
11.18±0.40(Predicted) | [color ]
White to yellow | [InChIKey]
XSLGWYQNBQGZTG-MCZRLCSDSA-N |
| Hazard Information | Back Directory | [Uses]
Deruxtecan is an ADC drug-linker conjugate composed of a derivative of DX-8951 (DXd) and a maleimide-GGFG peptide linker, used for synthesizing DS-8201 and U3-1402. | [Indications]
By Deruxtecan Preparation Trastuzumab deruxtecan drug is approved by the FDA for the treatment of patients with any HER2-positive advanced solid tumour (e.g., breast, gastric, and GOJ adenocarcinomas) and only after the patient has previously received other advanced treatments. | [Mechanism of action]
Deruxtecan is attached to the antibody by a peptide linker. After trastuzumab deruxtecan binds to HER2 found on malignant cells, it is internalized and linker cleavage occurs through the actions of lysosomal enzymes. After it is released through cleavage, DXd causes targeted DNA damage and apoptosis in cancer cells, due to the ability to cross cell membranes. | [Side effects]
The most common side effects of Deruxtecan (Trastuzumab deruxtecan) include: nausea, vomiting, diarrhoea, fatigue, hair loss, increased risk of infections (low white blood cell counts, red blood cell counts, and platelet counts), breathlessness, coughing, headache, bone or muscle pain, mouth ulcers, loss of appetite, weight loss, heart problems, liver or skin changes, low potassium levels. All of these side effects may not always occur at the same time and will vary from person to person. Serious adverse reactions include: interstitial lung disease/pneumonia, serious impairment of heart function and allergic reactions. Special care should be taken to contact your doctor in case of any serious adverse reactions. | [IC 50]
Camptothecins |
|
| Company Name: |
YJ Pharma Gold
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| Telephone: |
13962794339 |
| Website: |
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| Company Name: |
Wuhan Topule Gold
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
ChemCell Biomedicine Co.,Ltd.
|
| Telephone: |
020-13556033878 2965585218 13556033878 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList15061/0_EN.htm |
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