| Identification | Back Directory | [Name]
2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide | [CAS]
1462267-08-8 | [Synonyms]
ML266
133974
CS-2740
CID-46943215
2-(2-((4-bromophenyl)amino)-2-oxoethoxy)-N-(2-(methyl(phenyl)amino)-2-oxoethyl)benzamide
Benzamide, 2-[2-[(4-bromophenyl)amino]-2-oxoethoxy]-N-[2-(methylphenylamino)-2-oxoethyl]- | [EINECS(EC#)]
604-604-1 | [Molecular Formula]
C24H22BrN3O4 | [MDL Number]
MFCD29477343 | [MOL File]
1462267-08-8.mol | [Molecular Weight]
496.35 |
| Chemical Properties | Back Directory | [Boiling point ]
724.2±60.0 °C(Predicted) | [density ]
1.445±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.31±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ML266 is glucocerebrosidase (GCase) molecule chaperone with IC50 of 2.5 μM. ML266 binds to GCase and transports of the mutant protein to the lysosome, and resume the activity of GCase. ML266 dose not inhibit the GCase enzyme’s action. ML266 has the potential for the research of gaucher disease[1]. | [References]
[1] Rogers S, et al. Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase. 2012 Mar 27 [updated 2013 Mar 7]. PMID:23762943 |
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