ChemicalBook--->CAS DataBase List--->146255-66-5

146255-66-5

146255-66-5 Structure

146255-66-5 Structure
IdentificationBack Directory
[Name]

(RS)-3,5-DHPG
[CAS]

146255-66-5
[Synonyms]

(RS)-3,5-DHPG
3,5-dihydroxyphenylglycine
(RS)-3,5-DIHYDROXYPHENYLGLYCINE
DL-ALPHA-(3,5-DIHYDROXYPHENYL)GLYCINE
Benzeneacetic acid, α-amino-3,5-dihydroxy-
2-amino-2-(3,5-dihydroxyphenyl)acetic acid
a-Amino-3,5-dihydroxy-benzeneacetic acid HCl
[Molecular Formula]

C8H9NO4
[MDL Number]

MFCD00272595
[MOL File]

146255-66-5.mol
[Molecular Weight]

183.16
Chemical PropertiesBack Directory
[Boiling point ]

448.8±33.0 °C(Predicted)
[density ]

1.550±0.06 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMSO: 1 mg/ml; Water: 1 mg/ml
[form ]

A solid
[pka]

1.77±0.10(Predicted)
[color ]

White
[Water Solubility ]

Soluble in water (10mM)
[Stability:]

Hygroscopic
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H302-H315-H319-H335
[Precautionary statements ]

P261-P264-P270-P271-P280-P301+P312-P330-P302+P352-P321-P304+P340-P305+P351+P338-P332+P313-P362+P364-P337+P313-P403+P233-P405-P501
Hazard InformationBack Directory
[Uses]

(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGluR1 and mGluR5. It has been shown that (RS)-3,5-DHPG can modulate Kir4.1 protein and mRNA in cultured rat retinal Müller cells.(RS)-3,5-DHPG acts as a potential target in treatment of parkinson''s disease.
[Definition]

ChEBI: A glycine derivative that is L-alpha-phenylglycine substituted at positions 3 and 5 on the phenyl ring by hydroxy groups.
[IC 50]

mGluR 1; mGluR 5
[storage]

-20°C (desiccate). Protect from light.
Spectrum DetailBack Directory
[Spectrum Detail]

(RS)-3,5-DHPG(146255-66-5)1HNMR
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