| Identification | Back Directory | [Name]
FR901464 | [CAS]
146478-72-0 | [Synonyms]
FR901464
WB 2663B
PJKVJJDQXZARCA-QHYZBLTGSA-N
2-Pentenamide, 4-(acetyloxy)-N-[(2R,3R,5S,6S)-6-[(2E,4E)-5-[(3R,4R,5R,7S)-4,7-dihydroxy-7-methyl-1,6-dioxaspiro[2.5]oct-5-yl]-3-methyl-2,4-pentadien-1-yl]tetrahydro-2,5-dimethyl-2H-pyran-3-yl]-, (2Z,4S)- | [Molecular Formula]
C27H41NO8 | [MDL Number]
MFCD27665477 | [MOL File]
146478-72-0.mol | [Molecular Weight]
507.62 |
| Hazard Information | Back Directory | [Description]
FR901464 is a potent anticancer moecule that lowers the mRNA levels of oncogenes and tumor suppressor genes. | [Uses]
FR901464 is a potent spliceosome inhibitor with prominent anti-tumor and anti-cancer effects[1]. | [Definition]
ChEBI: A spiro-epoxide with potent anticancer activity that lowers the mRNA levels of oncogenes and tumour supressor genes. It is isolated from Pseudomonas sp. no.2663. | [References]
[1] H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. II. Activities against experimental tumors in mice and mechanism of action. J Antibiot (Tokyo). 1996 Dec;49(12):1204-11. DOI:10.7164/antibiotics.49.1204
[2] Arun K Ghosh, et al. Enantioselective total syntheses of FR901464 and spliceostatin A and evaluation of splicing activity of key derivatives. J Org Chem. 2014 Jun 20;79(12):5697-709. DOI:10.1021/jo500800k |
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