146478-74-2

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146478-74-2 Structure

Identification	Back Directory
[Name] FR901463
[CAS] 146478-74-2
[Synonyms] FR901463 F 901463 WB 2663A RONUKPQOBQKEHX-QHYZBLTGSA-N
[Molecular Formula] C27H42ClNO8
[MDL Number] MFCD28347813
[MOL File] 146478-74-2.mol
[Molecular Weight] 544.077

Hazard Information	Back Directory
[Uses] FR901463 is a potent anti-cancer agent and can be used for cancer research. FR901463 enhances the transcriptional activity of the promoter of SV40 DNA virus[1].
[Definition] ChEBI: A cyclic hemiketal isolated from the fermentation broth of Pseudomonas sp.no.2663. It displays potent cytotoxic activity against human tumour cells.
[References] [1] H Nakajima, et al. New antitumor substances, FR901463, FR901464 and FR901465. I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Dec;49(12):1196-203. DOI:10.7164/antibiotics.49.1196

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