| Identification | Back Directory | [Name]
makaluvamine A | [CAS]
146555-78-4 | [Synonyms]
makaluvamine A
7-Amino-3,4-dihydro-1-methylpyrrolo[4,3,2-de]quinolin-8(1H)-one
Pyrrolo[4,3,2-de]quinolin-8(1H)-one, 7-amino-3,4-dihydro-1-methyl- | [Molecular Formula]
C11H11N3O | [MOL File]
146555-78-4.mol | [Molecular Weight]
201.22 |
| Hazard Information | Back Directory | [Description]
Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors. | [Uses]
Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells[1]. | [References]
[1] An J, et al. Pyrroloiminoquinone Alkaloids: Total Synthesis of Makaluvamines A and K. Org Lett. 2023 Mar 24;25(11):1868-1871. DOI:10.1021/acs.orglett.3c00350 |
|
|