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147159-51-1

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147159-51-1 Structure

147159-51-1 Structure
IdentificationBack Directory
[Name]

TT 232
[CAS]

147159-51-1
[Synonyms]

L-ThreoninaMide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-, cyclic (2→6)-disulfide
[Molecular Formula]

C45H58N10O9S2
[MDL Number]

MFCD00926026
[MOL File]

147159-51-1.mol
[Molecular Weight]

947.13
Chemical PropertiesBack Directory
[Boiling point ]

1409.4±65.0 °C(Predicted)
[density ]

1.42±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[form ]

Powder
[pka]

9.90±0.15(Predicted)
[color ]

White to off-white
[Water Solubility ]

Soluble to 1 mg/ml in water
Hazard InformationBack Directory
[Uses]

TT 232 is a synthetic heptapeptide, which is an analog of somatostatin.
[in vivo]

TT-232 (15-750 μg/kg/day, twice a day) inhibits tumor growth in mice transplanted with Colon 26 cell[2].
TT-232 (0.6 or 15 μg/kg s.c or i.p.) shows antitumor effect on P-388 rodent lymphocytic leukemia tumor mice[3].
TT-232 (7.5-20 μg/kg, i.v.) inhibits Carrageenin-induced paw oedema in rats[4].

Animal Model:Mice transplanted with Colon 26 cell [2].
Dosage:15, 150, 750 μg/kg/day
Administration:Intraperitoneal injection (i.p.)
Result:Reached 70% tumor inhibition at 750 μg/kg.
[IC 50]

SSTR1; SSTR4
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