| Identification | Back Directory | [Name]
TT 232 | [CAS]
147159-51-1 | [Synonyms]
L-ThreoninaMide, D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-cysteinyl-, cyclic (2→6)-disulfide | [Molecular Formula]
C45H58N10O9S2 | [MDL Number]
MFCD00926026 | [MOL File]
147159-51-1.mol | [Molecular Weight]
947.13 |
| Chemical Properties | Back Directory | [Boiling point ]
1409.4±65.0 °C(Predicted) | [density ]
1.42±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [form ]
Powder | [pka]
9.90±0.15(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in water |
| Hazard Information | Back Directory | [Uses]
TT 232 is a synthetic heptapeptide, which is an analog of somatostatin. | [in vivo]
TT-232 (15-750 μg/kg/day, twice a day) inhibits tumor growth in mice transplanted with Colon 26 cell[2].
TT-232 (0.6 or 15 μg/kg s.c or i.p.) shows antitumor effect on P-388 rodent lymphocytic leukemia tumor mice[3].
TT-232 (7.5-20 μg/kg, i.v.) inhibits Carrageenin-induced paw oedema in rats[4].
| Animal Model: | Mice transplanted with Colon 26 cell [2]. | | Dosage: | 15, 150, 750 μg/kg/day | | Administration: | Intraperitoneal injection (i.p.) | | Result: | Reached 70% tumor inhibition at 750 μg/kg. |
| [IC 50]
SSTR1; SSTR4 |
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