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147267-10-5

147267-10-5 Structure

147267-10-5 Structure
IdentificationBack Directory
[Name]

NPC 17731
[CAS]

147267-10-5
[Synonyms]

NPC 17731
[Molecular Formula]

C59H95N19O14
[MOL File]

147267-10-5.mol
[Molecular Weight]

1294.5
Chemical PropertiesBack Directory
[Sequence]

Arg-Arg-Pro-{Hyp}-Gly-Phe-Ser-{Hyp}-{Oic}-Arg
Hazard InformationBack Directory
[Description]

NPC 17731 is a bradykinin receptor antagonist.
[Uses]

NPC 17731 is a new bradykinin (BK) receptor antagonist. NPC 17731 antagonized both the contractile and relaxant responses caused by BK in longitudinal smooth muscle with IC50 of 23 and 29 nM, respectively[1].
[References]

[1] Y S Medeiros, et al. Competitive and selective antagonistic action of NPC 17731 on bradykinin-induced relaxant and contractile responses of the guinea pig isolated ileum. Gen Pharmacol. 1995 Nov;26(7):1507-11. DOI:10.1016/0306-3623(95)00031-3
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