| Identification | Back Directory | [Name]
Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- | [CAS]
1474022-02-0 | [Synonyms]
PF 05381941,PF05381941
Urea, N-[1-(3-cyanophenyl)-3-(1,1-dimethylethyl)-1H-pyrazol-5-yl]-N'-[3-methyl-4-(4-pyridinyloxy)phenyl]- | [Molecular Formula]
C27 H26 N6 O2 | [MDL Number]
MFCD34578211 | [MOL File]
1474022-02-0.mol | [Molecular Weight]
466.53 |
| Chemical Properties | Back Directory | [Boiling point ]
561.0±50.0 °C(Predicted) | [density ]
1.21±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 100 mg/mL (214.35 mM; Need ultrasonic) | [form ]
Solid | [pka]
13.37±0.70(Predicted) | [color ]
Off-white to brown |
| Hazard Information | Back Directory | [Uses]
PF-05381941 is a potent dual inhibitor of TAK1/p38α, with IC50s of 156 and186 nM, respectively[1]. | [IC 50]
p38α: 186 nM (IC50); TAK1: 156 nM (IC50) | [storage]
Store at -20°C | [References]
[1] Kilty I, et al. TAK1 inhibition in the DFG-out conformation. Chem Biol Drug Des. 2013;82(5):500-505. DOI:10.1111/cbdd.12169 |
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