| Identification | Back Directory | [Name]
DESETHYL CHLOROQUINE | [CAS]
1476-52-4 | [Synonyms]
WR 29623
NSC 13254
Deethylchloroquine
DESETHYL CHLOROQUINE
Chloroquine USP RC D
Monodeethylchloroquine
Monodesethylchloroquine
Desethyl Chloroquine sulfate
Chloroquine Related CoMpound D
Hydroxychloroquine Impurity 9 2HBr
Chloroquine Impurity 1（Desethyl Chloroquine）
Hydroxychloroquine Sulfate EP Impurity D DiHBr
N'-(7-Chloroquinolin-4-yl)-N-ethyl-1,4-pentanediamine
Hydroxychloroquine EP Impurity D/Desethyl Chloroquine
N4-(7-Chloro-4-quinolinyl)-N1-ethyl-1,4-pentanediamine
N4-(7-chloroquinolin-4-yl)-N1-ethyl-pentane-1,4-diamine
4-N-(7-chloroquinolin-4-yl)-1-N-ethylpentane-1,4-diamine
1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1-ethyl-
N-[1-Methyl-4-(ethylamino)butyl]7-chloro-4-quinolinamine
4-[[1-Methyl-4-(ethylamino)butyl]amino]-7-chloroquinoline
7-Chloro-4-{[4-(ethylamino)-1-methylbutyl]amino}quinoline
N-[4-(Ethylamino)-1-methylbutyl]-7-chloroquinoline-4-amine
(7-chloro-4-quinolyl)-[4-(ethylamino)-1-methyl-butyl]amine
Desethyl Chloroquine DiHBr (Hydroxychloroquine Sulfate EP Impurity D DiHBr)
Hydroxychloroquine Sulfate Impurity 4（Hydroxychloroquine Sulfate EP Impurity D） | [Molecular Formula]
C16H22ClN3 | [MDL Number]
MFCD00871808 | [MOL File]
1476-52-4.mol | [Molecular Weight]
291.82 |
| Chemical Properties | Back Directory | [Melting point ]
94-97?C | [Boiling point ]
173-175 °C(Press: 0.05 Torr) | [density ]
1.138±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer | [solubility ]
Chloroform (Slightly), Dichloromethane (Slightly), Ethyl Acetate (Slightly), Met | [form ]
Solid | [pka]
10.62±0.19(Predicted) | [color ]
Pale Yellow to Dark Yellow | [biological source]
synthetic | [InChI]
1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20) | [InChIKey]
MCYUUUTUAAGOOT-UHFFFAOYSA-N | [SMILES]
ClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2 |
| Safety Data | Back Directory | [WGK Germany ]
3 | [HS Code ]
2933497050 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral |
| Hazard Information | Back Directory | [Chemical Properties]
DESETHYL CHLOROQUINE is Tan Solid
| [Uses]
The major product of the stereoselective human metabolism of Chloroquine, used for the therapy and prevention of malaria | [Definition]
ChEBI: Desethylchloroquine is an aminoquinoline. | [in vivo]
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame[3]. | [IC 50]
Plasmodium; TLRs |
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