1476-52-4
中文名称
羟基氯喹EP杂质D-d5二盐酸
英文名称
DESETHYL CHLOROQUINE
CAS
1476-52-4
分子式
C16H22ClN3
分子量
291.82
MOL 文件
1476-52-4.mol
更新日期
2026/01/28 16:42:32
1476-52-4 结构式
基本信息
中文别名
脱乙基氯喹去乙基氯喹
羟氯喹杂质D
氯喹相关物质D
去乙基哌拉西林
去乙基氯喹-D4
去乙基硫酸羟氯喹
去乙基氯喹HBR
羟基氯喹EP杂质D
去乙基羟氯喹HBR
英文别名
WR 29623NSC 13254
Deethylchloroquine
DESETHYL CHLOROQUINE
Chloroquine USP RC D
Monodeethylchloroquine
Monodesethylchloroquine
Desethyl Chloroquine sulfate
Chloroquine Related CoMpound D
Hydroxychloroquine Impurity 9 2HBr
所属类别
分析化学：药典标准品和杂质标准品物理化学性质
熔点94-97?C
沸点173-175 °C(Press: 0.05 Torr)
密度1.138±0.06 g/cm3(Predicted)
储存条件-20°C冷冻
溶解度可溶于氯仿（少量）、二氯甲烷（少量）、乙酸乙酯（少量）
酸度系数(pKa)10.62±0.19(Predicted)
形态固体
颜色淡黄色至深黄色
生物来源synthetic
InChI1S/C16H22ClN3/c1-3-18-9-4-5-12(2)20-15-8-10-19-16-11-13(17)6-7-14(15)16/h6-8,10-12,18H,3-5,9H2,1-2H3,(H,19,20)
InChIKeyMCYUUUTUAAGOOT-UHFFFAOYSA-N
SMILESClC(C=C1)=CC2=C1C(NC(CCCNCC)C)=CC=N2
常见问题列表
生物活性
Desethyl chloroquine 是 Chloroquine 的主要去乙基代谢产物。Chloroquine 是一种自噬和 toll-like receptors (TLRs) 的抑制剂。Desethyl chloroquine 具有抗疟原虫活性。体外研究
P. falciparum
体内研究
Intraperitoneal injections of Chloroquine are administered to wild-type and Huntington's disease (Q175/Q175) mice. LC-MS/MS is used to compare the levels Chloroquine and its metabolites in blood, brain and muscle tissue. Concentrations of Chloroquine are lower (5-15M), but more stable in brain tissue compared to blood or muscle between 4 and 24 hours after the last dose. Levels of the active Chloroquine metabolite Desethyl chloroquine decreased in muscle and blood over the 24 hour post-injection period, while brain Desethyl chloroquine levels are lower and rose slightly over the same time frame.