| Identification | Back Directory | [Name]
DCG IV | [CAS]
147782-19-2 | [Synonyms]
DCG IV
2-(2,3-dicarboxycyclopropyl)glycine
(2S,2'R,3'R)-2-(2',3'-DICARBOXYCYCLOPROPYL)GLYCINE
1,2-Cyclopropanedicarboxylic acid, 3-[(S)-aminocarboxymethyl]-, (1R,2R)- | [Molecular Formula]
C7H9NO6 | [MDL Number]
MFCD00673968 | [MOL File]
147782-19-2.mol | [Molecular Weight]
203.15 |
| Chemical Properties | Back Directory | [Boiling point ]
503.9±40.0 °C(Predicted) | [density ]
1.819±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at RT | [solubility ]
Water (Slightly) | [form ]
Powder | [pka]
2.40±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
DCG IV (cas# 147782-19-2) is a useful research chemical.DCG IV is a group-??II metabotropic glutamate (mGlu) receptor agonist. DCG-IV protected mouse cortical neurons grown in mixed cultures against excitotoxic degeneration induced by a 10 min pulse with NMDA. | [Biological Activity]
Presynaptic depressant; highly potent agonist for group II mGlu receptors. Also available as part of the Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™ . | [in vivo]
DCG-IV (1-10 mg/kg; i.p.) depresses the phencyclidine (PCP)-induced hyperlocomotion[4]. | Animal Model: | Male ICR mice weighing about 40 g (PCP-induced locomotor activity)[4] | | Dosage: | 10, 5, or 1 mg/kg | | Administration: | I.p. | | Result: | Reduced spontaneous activities of the animals at 10 or 5 mg/kg.
|
| [IC 50]
mGluR2R: 0.35 μM (EC50); mGluR3R: 0.09 μM (EC50); mGluR1R: 389 μM (IC50); mGluR5: 630 μM (IC50); mGluR4R: 22.5 μM (IC50); mGluR6: 39.6 μM (IC50); mGluR7: 40.1 μM (IC50); mGluR8: 32 μM (IC50) | [storage]
Store at -20°C |
|
| Company Name: |
|
| Tel: |
821-50328103-801 18930552037 |
| Website: |
https://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm |
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Website: |
www.rndsystems.com |
|