| Identification | Back Directory | [Name]
HUMAN IL-13 | [CAS]
148157-34-0 | [Synonyms]
ALRH
BHR1
P600
IL-13
RHIL-13
HUMAN NC30
Aids059207
Aids-059207
HUMAN IL-13
IL-13, HUMAN
INTERLEUKIN 13
IL-13 from rat
IL-13 Variant human
Human IL-13 Protein
HUMAN INTERLEUKIN 13
INTERLEUKIN-13, HUMAN
RECOMBINANT HUMAN IL-13
IL-13 Long Form from rat
Interleukin-13 from mouse
NC300 (Human) P600 (Murine)
Interleukin-13, Human, Recomb.
Mouse Interleukin 13 elisa kit
INTERLEUKIN-13, HUMAN, RECOMBINANT
Recombinant Human IL13 Protein, Fc Tag
INTERLEUKIN-13 (IL-13), HUMAN, RECOMBINANT
Interleukin-13, Human, Recombinant, E. coli
Recombinant Mouse Il-13/Il13 Protein, No Tag
Recombinant Mouse Il-13/Il13 Protein, His Tag
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Interleukin-13 human >=97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, cell culture tested | [MDL Number]
MFCD00212209 |
| Hazard Information | Back Directory | [General Description]
Interleukin-13 (IL-13) is an immunoregulatory cytokine produced primarily by activated T-helper 2 (Th2) cells,and also by mast cells and natural killer (NK) cells. The gene encoding it is localized on human chromosome 5q31. Human and murine IL-13 is cross-species reactive. Recombinant human IL-13 is a 12.6kDa protein consisting of 115 amino acid residues. | [Biochem/physiol Actions]
Interleukin-13 (IL-13) has a role in immune activities against infections and influences the function of various cells taking part in the same. It has been studied to be overexpressed in glioblastoma tumors and cell lines. IL-13 stimulates fibrosis in many infectious diseases. Targeted deletion of IL-13 in mice resulted in impaired T-helper 2 (Th2) cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukins-1β, -6 and -8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of immunoglobulin E (IgE). Blocking of IL-13 activity inhibits the pathophysiology of asthma. |
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