| Identification | Back Directory | [Name]
RIPK1-IN-4 | [CAS]
1481641-08-0 | [Synonyms]
RIPK1-IN-4
Urea, N-[4-(1-amino-5-isoquinolinyl)phenyl]-N'-[5-(1,1-dimethylethyl)-3-isoxazolyl]- | [Molecular Formula]
C23H23N5O2 | [MOL File]
1481641-08-0.mol | [Molecular Weight]
401.46 |
| Chemical Properties | Back Directory | [Boiling point ]
535.8±50.0 °C(Predicted) | [density ]
1.305±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO: 250 mg/mL (622.73 mM) | [form ]
Solid | [pka]
12.71±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1]. | [IC 50]
RIPK1 | [storage]
Store at -20°C | [References]
[1] Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43. DOI:10.1021/ml400382p |
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