| Identification | Back Directory | [Name]
GDP-D-mannose disodium salt | [CAS]
148296-46-2 | [Synonyms]
GDP-α-D-mannose disodium
GDP-?α-D-?mannose disodium
GDP-D-mannose disodium salt
Guanosine 5'-(trihydrogen diphosphate) P'-alpha-D-mannopyranosyl ester disodium salt | [Molecular Formula]
C16H23N5Na2O16P2 | [MDL Number]
MFCD00799981 | [MOL File]
148296-46-2.mol | [Molecular Weight]
649.305 |
| Hazard Information | Back Directory | [Uses]
GDP-α-D-mannose disodium is the donor substrate for mannosyltransferases and the precursor of GDP-β-L-fucose. GDP-α-D-mannose disodium gives a competitive inhibition with respect to GTP (Ki 14.7 μM) and an uncompetitive inhibition with respect to mannose-1-P (Ki 115 μM)[1]. | [Biochem/physiol Actions]
Intermediate in fructose and mannose metabolism, ascorbate and aldarate metabolism, amino sugar and nucleotide sugar metabolism and N-Glycan biosynthesis. | [IC 50]
Human Endogenous Metabolite | [References]
[1] Elling L, et al. Expression, purification and characterization of recombinant phosphomannomutase and GDP-alpha-D-mannose pyrophosphorylase from Salmonella enterica, group B, for the synthesis of GDP-alpha-D-mannose from D-mannose. Glycobiology. 1996 Sep;6(6):591-7. DOI:10.1093/glycob/6.6.591 |
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