| Identification | More | [Name]
3,4-Methylenedioxy-beta-nitrostyrene | [CAS]
1485-00-3 | [Synonyms]
1-(3,4-METHYLENEDIOXYPHENYL) 2-NITROETHENE
3,4-METHYLENEDIOXY-BETA-NITROSTYRENE
3,4-METHYLENEDIOXY-B-NITROSTYRENE
3,4-METHYLENEDIOXYNITROSTYRENE
5-[(E)-2-NITROVINYL]-1,3-BENZODIOXOLE
AKOS BBS-00006781
TIMTEC-BB SBB007833
-(2-Nitrovinyl)-1,3-benzodioxole
-(2-Nitrovinyl)-3,4-methylenedioxybenzene
,4-(Methylenedioxy)-b-nitrostyrene
,4-Methylenedioxy-1-(2-nitrovinyl)benzene
1,3-Benzodioxole, 5-(2-nitroethenyl)-
1,3-Benzodioxole, 5-nitrovinyl-
3,4-methylenedioxy-beta-nitro-styren
3,4-Methylenedioxy-omega-nitrostyrene
5-[(E)-2-Nitroethenyl]-1,3-benzodioxole
5-nitrovinyl-3-benzodioxole
Benzene, 2-nitroethenyl, 3,4-methylenedioxy
Ethene,-1-(3,4-methylendioxyphenyl)-2-nitro-
Styrene, 3,4-methylenedioxy-beta-nitro- | [EINECS(EC#)]
622-830-8 | [Molecular Formula]
C9H7NO4 | [MDL Number]
MFCD00014575 | [Molecular Weight]
193.16 | [MOL File]
1485-00-3.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow powder | [Melting point ]
159-163 °C | [Boiling point ]
329.36°C (rough estimate) | [density ]
1.4058 (rough estimate) | [refractive index ]
1.5200 (estimate) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO (up to 50 mg/ml). | [form ]
Yellow to brown solid | [color ]
Yellow | [Sensitive ]
Light Sensitive | [BRN ]
192350 | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. | [InChI]
InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2 | [InChIKey]
KFLWBZPSJQPRDD-UHFFFAOYSA-N | [SMILES]
O1C2=CC=C(C=C[N+]([O-])=O)C=C2OC1 | [CAS DataBase Reference]
1485-00-3(CAS DataBase Reference) | [NIST Chemistry Reference]
3,4-Methylenedioxy-«beta»-nitrostyrene(1485-00-3) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319 | [Precautionary statements ]
P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313 | [Hazard Codes ]
Xn,Xi,T | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed.
R25:Toxic if swallowed. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2811 6.1/PG 3 | [WGK Germany ]
WGK 3 | [RTECS ]
WL5270000 | [HS Code ]
29329990 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Description]
MDBN (1485-00-3) is an irreversible inhibitor of p97 (IC50 < 10 μM). Cell permeable. | [Chemical Properties]
yellow powder | [Uses]
MDBN is a Src and Syk kinase inhibitor that prevents phosphorylation and cytoskeletal association of GPIIb/IIIa and talin. | [Biological Activity]
Selective inhibitor of Src and Syk tyrosine kinases. Displays antiaggregative activity via inhibition of GPIIb/IIIa activation (IC 50 = 12.7 μ M for thrombin-induced platelet aggregation). Exhibits no effects on Ca 2+ -dependent enzymes, PKC or arachidonic acid metabolism. | [in vivo]
MNS (20 mg/kg, i.p.) ameliorates experimental burn wound progression in Wistar rats by inhibiting the NLRP3 inflammasome activation[7].
MNS (30 mg/kg, p.o., 5 days) alleviates DSS-induced mouse colitis by inhibiting the NLRP3 inflammasome[8].
MNS (20?mg/kg, i.p., 30?min before reperfusion) significantly protects the kidneys from RIR injury in rats by reducing PANoptosis through specific inhibition of NLRP3[9].
| [IC 50]
NLRP3 inflammasome | [References]
1) Chou et al. (2011), Quantitative cell-based protein degradation assays to identify and classify drugs that target the ubiquitin-proteasome system; J. Biol. Chem., 286 16546 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|