| Identification | Back Directory | [Name]
L-Glutamic acid,N-[4-[[2-(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]- | [CAS]
14866-11-6 | [Synonyms]
Dihydrohomofolic acid
L-Glutamic acid,N-[4-[[2-(2-amino-3,4,7,8-tetrahydro-4-oxo-6-pteridinyl)ethyl]amino]benzoyl]- | [Molecular Formula]
C20H23N7O6 | [MOL File]
14866-11-6.mol | [Molecular Weight]
457.44 |
| Hazard Information | Back Directory | [Description]
Dihydrohomofolic acid is a substrate for dihydrofolate reductase; produces tetrahydrohomofolate which in turn inhibits thymidylate synthetase & therefore DNA synthesis. | [Uses]
Dihydrohomofolic acid, an analog of dihydrofolic acid (H2F), might be effective against tumor in which resistance to methotrexate (MTX) is associated with high leveIs of H2F-reductase[1]. | [References]
[1] L C Mishra, et al. Effect of pretreatment with methotrexate on the reduction of dihydrohomofolic acid in mice. Biochem Pharmacol. 1971 Oct;20(10):2871-8. DOI:10.1016/0006-2952(71)90198-5 |
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