| Identification | Back Directory | [Name]
3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE | [CAS]
148687-76-7 | [Synonyms]
L-733,060 HYDROCHLORIDE
L-733,061 HYDROCHLORIDE
3-([3,5-BIS(TRIFLUOROMETHYL)PHENYL]METHOXY)-2-PHENYL-PIPERIDINE HYDROCHLORIDE | [Molecular Formula]
C20H20ClF6NO | [MDL Number]
MFCD01862671 | [MOL File]
148687-76-7.mol | [Molecular Weight]
439.82 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C
| [solubility ]
DMSO: >10 mg/mL
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble to 50 mM in water with gentle warming |
| Hazard Information | Back Directory | [Uses]
L-733,060 Hydrochloride is an NK-1 inhibitor which is used in the treatment of depression and nausea, associated with cancer chemotherapy. | [in vivo]
L-733060 (10-1000 μg/kg; i.v.) inhibits electrically stimulated plasma extravasation in dura mater of rats[1].
L-733060 (300-3000 μg/kg; i.v.) has no significant hypotensive or bradycardic effects are observed at doses of <3000 μg/kg in conscious or anaesthetised rats[1]. | Animal Model: | Male Sprague-Dawley rats (200 g) with electrical stimulation of the trigeminal ganglion[1] | | Dosage: | 10, 100, 1000 mg/kg | | Administration: | I.v. injection | | Result: | Produced a significant dose-related inhibition of plasma extravasation with an ID50 of 212±19 μg/kg. |
| [IC 50]
NK1 | [storage]
Store at RT |
|
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