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148707-39-5

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148707-39-5 Structure

148707-39-5 Structure
IdentificationBack Directory
[Name]

AcEGCG
[CAS]

148707-39-5
[Synonyms]

AcEGCG
EGCG Octaacetate
Epigallocatechin gallate octaacetate
Peracetylated epigallocatechin-3-gallate
(-)-Epigallocatechin gallate octaacetate ester
Benzoic acid, 3,4,5-tris(acetyloxy)-, (2R,3R)-5,7-bis(acetyloxy)-3,4-dihydro-2-[3,4,5-tris(acetyloxy)phenyl]-2H-1-benzopyran-3-yl ester
[Molecular Formula]

C38H34O19
[MOL File]

148707-39-5.mol
[Molecular Weight]

794.67
Chemical PropertiesBack Directory
[Melting point ]

114.3-115.1 °C
[Boiling point ]

879.7±65.0 °C(Predicted)
[density ]

1.46±0.1 g/cm3(Predicted)
[storage temp. ]

4°C, protect from light
[solubility ]

DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml,DMSO: 15 mg/ml
[form ]

Solid
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

EGCG Octaacetate (AcEGCG) is a proagent of Green tea epigallocatechin-3-gallate (EGCG). EGCG Octaacetate decreases the proinflammatory mediator levels by down-regulating of PI3K/Akt/NFκB phosphorylation and p65 acetylation. EGCG Octaacetate reduces colitis-driven colon cancer in mice. EGCG octaacetate is the potential antibacterial compound for gram-positive bacteria (GPB) and gram-negative bacteria (GNB)[1][2][3].
[storage]

4°C, protect from light
[References]

[1] Wang CC, et al. Prodrug of green tea epigallocatechin-3-gallate (Pro-EGCG) as a potent anti-angiogenesis agent for endometriosis in mice. Angiogenesis. 2013 Jan;16(1):59-69. DOI:10.1007/s10456-012-9299-4
[2] KalaiselviIgnasimuthu, et al. Enhanced bioaccessibility of green tea polyphenols and lipophilic activity of EGCG octaacetate on gram-negative bacteria. Volume 105, May 2019, Pages 103-109.
[3] Yi-Shiou Chiou, et al. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently suppresses dextran sulfate sodium-induced colitis and colon tumorigenesis in mice. J Agric Food Chem. 2012 Apr 4;60(13):3441-51. DOI:10.1021/jf300441p
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