| Identification | More | [Name]
(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl-2-propenal | [CAS]
148901-68-2 | [Synonyms]
(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)-3-Quinolinyl-2-propenal
PT-4
(E)-3-[2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl]prop-2-en-1-al
(E)-3''-[4-(4''-FLUOROPHENYL)-2-(CYCLOPROPYL)-3-QUINOLINYL]-2-PROPENAL | [Molecular Formula]
C21H16FNO | [MDL Number]
MFCD09955496 | [Molecular Weight]
317.36 | [MOL File]
148901-68-2.mol |
| Hazard Information | Back Directory | [Synthesis]
The general procedure for the synthesis of (E)-3-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]acrolein from the compound (CAS: 113832-57-8) and 2-cyclopropyl-4-(4-fluorophenyl)quinoline-3-carboxaldehyde is as follows: the general procedure is as follows: except for the use of ethylidene cyclohexylamine (1.7 g, 13.8 mmol) in place of the ethylidene tert-butylamine (1.4 g, 14.1 mmol), the operation was the same as in Example 1. A portion of the reaction mixture was poured into 10% (w/v) aqueous acetic acid solution and analyzed by high performance liquid chromatography (HPLC) using the internal standard method. The analytical results showed that (E)-3-[4'-(4"-fluorophenyl)-2'-cyclopropylquinolin-3'-yl]propanal (1.7 g, 5.4 mmol, 78.3% yield) was successfully synthesized. | [References]
[1] Patent: EP1614682, 2006, A1. Location in patent: Page/Page column 6 |
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