| Identification | More | [Name]
1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA | [CAS]
14901-16-7 | [Synonyms]
1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
1-PHENYL-3-(THIAZOL-2-YL)THIOUREA
1-phenyl-3-(2-thiazolyl)-2-thio-ure
n-phenyl-n’-2-thiazolyl-thioure
phenylthiazolylthiourea
1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA 97&
Urea, 1-phenyl-3-(2-thiazolyl)-2-thio.
1-Phenyl-3-(2-thiazolyl)thiourea
N-Phenyl-N'-(2-thiazolyl)thiourea
N-Phenyl-N'-(thiazol-2-yl)thiourea
U-14624 | [EINECS(EC#)]
238-970-4 | [Molecular Formula]
C10H9N3S2 | [MDL Number]
MFCD00005321 | [Molecular Weight]
235.33 | [MOL File]
14901-16-7.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [WGK Germany ]
3
| [RTECS ]
YU1398000
|
| Hazard Information | Back Directory | [Chemical Properties]
light brown fine crystalline powder | [Uses]
U-14624 is a potent and orally active dopamine beta-hydroxylase inhibitor. U-14624 suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes[1][2]. | [in vivo]
U-14624 (50 mg/kg; i.p.; daily for 5-7 days) suppresses the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes in rats[2]. | Animal Model: | 150-260 g, Male Sprague-Dawley rats[2] | | Dosage: | 25 mg/kg | | Administration: | I.p.; daily for 3 days | | Result: | Prolonged the time required for clearance of pentobarbital from both the plasma and brain, slept significantly longer. |
| Animal Model: | 150-260 g, Male Sprague-Dawley rats[2] | | Dosage: | 50 mg/kg | | Administration: | I.p.; daily for 5-7 days | | Result: | Suppressed the activities of aminopyrine N-demethylase, aniline hydroxylase and p-nitroanisole O-demethylase enzymes. |
| [References]
[1] Von Voigtlander PF, et al. Behavioral and brain catecholamine depleting actions of U-14,624, an inhibitor of dopamine beta-hydroxylase. Proc Soc Exp Biol Med. 1970 Mar;133(3):817-20. DOI:10.3181/00379727-133-34571
[2] Smith JR, et al. Effect of the catecholamine-depleting agent 1-phenyl-3-(2-thiazolyl)-2-thiourea (U-14,624) on drug metabolism in the rat. Biochem Pharmacol. 1980 Sep 15;29(18):2425-30. DOI:10.1016/0006-2952(80)90345-7 |
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