| Identification | Back Directory | [Name]
N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride | [CAS]
149055-79-8 | [Synonyms]
3-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenyl-N-tert-butyl-propanamide dihydrochloride
N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride | [Molecular Formula]
C24H35Cl2N3O2 | [MDL Number]
MFCD00903910 | [MOL File]
149055-79-8.mol | [Molecular Weight]
468.46 |
| Chemical Properties | Back Directory | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥10mg/mL | [form ]
powder | [color ]
white to off-white | [Water Solubility ]
H2O: ≥10mg/mL | [InChI]
1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H | [InChIKey]
VJGZNBYDSDEOED-UHFFFAOYSA-N | [SMILES]
Cl.Cl.COc1ccccc1N2CCN(CC2)CC(C(=O)NC(C)(C)C)c3ccccc3 |
| Hazard Information | Back Directory | [Uses]
WAY-100135 is a selective and potent 5-HT1A receptor antagonist. | [Biological Activity]
WAY-100135 is a potentselective 5-HT1A receptor antagonist (IC50 = 15 nM). It is selective over 5-HT1B1C2,α1α2 and D2 receptors (IC50 > 1000 nM). | [in vivo]
WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats[1].
WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats[2]. | [IC 50]
5-HT1A Receptor: 34 nM (IC50) |
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| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
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