| Identification | More | [Name]
DIHYDROERGOTAMINE MESYLATE | [CAS]
6190-39-2 | [Synonyms]
9,10-DIHYDRO-12'-HYDROXY-2'-METHYL-5'-(PHENYLMETHYL)ERGOTAMAN-3',6',18-TRIONE MESYLATE
DIHYDROERGOTAMINE MESYLATE
DIHYDROERGOTAMINE METHANESULFONATE
DIHYDROERGOTAMINE METHANESULFONATE SALT
5'-Benzyl-12'-hydroxy-2'-methyl-3',6',18-trioxo-9,10-dihydroergotaman
9,10-Dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)ergotoman-3',6',18-trionemonomethanesulfonate
9,10-dihydroergotaminemesylate
9,10-dihydro-ergotaminmonomethanesulfonate(salt)
Agit
Angionorm
D.H.E. 45
Dergotamine
DET MS
detms
dhe45
DHE-45
Diergo
Dihydergot
Dihydroergotamine monomethanesulfonate
dihydroergotaminemesilate | [EINECS(EC#)]
228-235-6 | [Molecular Formula]
C34H41N5O8S | [MDL Number]
MFCD00058615 | [Molecular Weight]
679.78 | [MOL File]
6190-39-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
232°C | [refractive index ]
-20 ° (C=0.25, JP Method) | [storage temp. ]
Store at RT | [solubility ]
methanol: 21 mg/mL
| [form ]
powder
| [color ]
white
| [Merck ]
3174 | [Stability:]
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. | [CAS DataBase Reference]
6190-39-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36:Wear suitable protective clothing . | [RIDADR ]
1544 | [WGK Germany ]
3
| [RTECS ]
KE7920000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
2939690000 |
| Hazard Information | Back Directory | [Description]
Dihydroergotamine mesylate (6190-39-2) is a full agonist at serotonin 5HT1B and 5HT1D receptors, IC50= 2 and 2.2 nM respectively1 and also at 5HT1A and 5HT1F receptors2. One of the oldest agents for treatment of migraine.3 Also acts as a potent vasoconstrictor and alpha-adrenergic antagonist.4 | [Chemical Properties]
White to Off-White Solid | [Uses]
Agonist at vascular serotonin receptors; partial agonist at alpha-adrenergic and dopamine D2 receptors | [Uses]
vasoconstrictor, antimigraine | [Uses]
α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine. | [Definition]
ChEBI: The methanesulfonic acid salt of dihydroergotamine, a semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine. Both the mesylate and the tartrate salts are used for the treatment of migraine and orthostatic hypotens
on. | [Brand name]
D.H.E. 45 (Valeant); Migranal (Valeant)
. | [Biological Activity]
Partial α -adrenergic agonist. Partial D 2 dopaminergic receptor agonist. Competitive 5-HT antagonist. | [storage]
Room temperature | [References]
Lesage et al. (1998), Agnostic properties of alniditan, sumatriptan and dihydroergotamine on human 5-HT1B and 5-HT1D receptors expressed in various mammalian cell lines; J. Pharmacol., 123 1655
Silberstein (1997), The pharmacology of ergotamine and dihydroergotamine; Headache, 37 Suppl 1 S15
Silberstein and McCrory (2003), Ergotamine and dihydroergotamine: history, pharmacology, and efficacy; Headache, 43 144
Lipton (1997), Ergotamine tartrate and dihydroergotamine mesylate: safety profiles; Headache, 37 Suppl.1 S33 |
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