| Chemical Properties | Back Directory | [storage temp. ]
Store at RT | [solubility ]
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [in vivo]
Quipazine dimaleate (2.5, 5 and 7.5 mg/kg, one dose for once; i.p.) affects dietary self-selection of different macronutrient diets in male and female rats[1]. | Animal Model: | Male and female Wistar rats feed with different sources of the three macronutrients (Group 1: casein, corn starch, safflower oil. Group 2: egg protein, corn starch/sucrose, lard. Group S: casein hydrolysate, maltose dextrin, butter.)[1] | | Dosage: | 2.5, 5 and 7.5 mg/kg | | Administration: | Intraperitoneal injection; 2.5, 5 and 7.5 mg/kg, one dose for once | | Result: | Increased water intake and food intake of male rats from Group S, and reduced food intake of female rats from Group 1 and Group 2s at 2h post-injection. Reduced food intake in female rats from Group 2, reduced protein intake in female rats from Group 1. |
| [storage]
Store at RT | [References]
[1] R H P PORTER. Functional characterization of agonists at recombinant human 5-HT2A, 5-HT2B and 5-HT2C receptors in CHO-K1 cells[J]. British Journal of Pharmacology, 2009, 128 1: 13-20. DOI: 10.1038/sj.bjp.0702751
[2] G.B. SCHIAVI. Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding[J]. Neuropharmacology, 1994, 33 3: Pages 543-549. DOI: 10.1016/0028-3908(94)90085-x
[3] R. SAMANIN. Decrease of food intake by quipazine in the rat: relation to serotoninergic receptor stimulation[J]. Journal of Pharmacy and Pharmacology, 1977, 29 1: 53-54. DOI: 10.1111/j.2042-7158.1977.tb11241.x
[4] GRÉGOIRE COURTINE. Transformation of nonfunctional spinal circuits into functional states after the loss of brain input[J]. Nature neuroscience, 2009, 12 10: 1333-1342. DOI: 10.1038/nn.2401 |
|
| Company Name: |
BOC Sciences
|
| Tel: |
|
| Website: |
https://www.bocsci.com |
|