| Identification | Back Directory | [Name]
ETHYL-L-NIO (HYDROCHLORIDE) | [CAS]
150403-97-7 | [Synonyms]
ETHYL-L-NIO (HYDROCHLORIDE)
DWNWLIPSWIUXRG-FJXQXJEOSA-N
L-N5-(1-IMINOBUTYL)ORNITHINE HYDROCHLORIDE
EthylLNIO (hydrochloride),Ethyl L NIO (hydrochloride)
chloro (2S)-2-amino-5-(1-aminobutylideneamino)pentanoate | [Molecular Formula]
C9H18ClN3O2 | [MDL Number]
MFCD11113147 | [MOL File]
150403-97-7.mol |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 0.3 mg/ml; DMSO: 2 mg/ml; Ethanol: 2.5 mg/ml; PBS (pH 7.2): 5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Ethyl-L-NIO, the saturated analog of vinyl-L-NIO, is a modestly selective NOS inhibitor. The Ki values for inhibition of nNOS, eNOS, and iNOS by ethyl-L-NIO are 5.3, 18, and 12 μM, respectively, as determined using initial rate measurements. However when evaluating the Ki/Km ratio, ethyl-L-NIO does not show biologically significant selectivity for nNOS over eNOS, and instead favors iNOS (Ki/Km = 3.79, 5, and 0.96 μM, respectively). Although ethyl-L-NIO inhibits nNOS, it does not inactivate nNOS in the presence of NADPH and O2. | [Uses]
Ethyl-L-NIO hydrochloride is a potent and competitive human dimethylarginine dimethylaminohydrolase 1 (hDDAH-1) inhibitor with an IC50 of 70 μM and a Ki of 32 μM[1]. | [References]
[1] Kotthaus J, et al. Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads. Bioorg Med Chem. 2008 Dec 15;16(24):10205-9. DOI:10.1016/j.bmc.2008.10.058 |
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