| Identification | Back Directory | [Name]
NG-MONOMETHYL-L-ARGININE ACETATE | [CAS]
53308-83-1 | [Synonyms]
NMMA
L-NMMA
ANO 1020
L-NMMA ACETATE
H-ARG(ME)-OH ACOH
NMMA ACETATE SALT
NG-ME-L-ARG, ACOH
L-NMMA MONOACETATE
Tilarginine Acetate
Nα-Methyl-L-arginine
NW-METHYL-L-ARGININE
L-NMMA, ACETATE SALT
N-Monomethyl-L-arginine
L-NMMA, MONOACETATE SALT
NG-METHYL-L-ARGININE ACETATE
NG-MONOMETHYL-L-ARGININE ACETATE
Ngamma-methyl-L-arginine acetate
NG-METHYL-L-ARGININE ACETATE SALT
N-OMEGA-METHYL-L-ARGININE ACETATE
nω-methyl-l-arginine acetate salt
N-OMEGA-ME-L-ARG, MONOACETATE SALT
NG-MONOMETHYL-L-ARGININE MONACETATE
NG-MONOMETHYL-L-ARGININE MONOACETATE
NOMEGA-MONOMETHYL-L-ARGININE ACETATE
N-Monomethyl-L-arginine monoacetate.
NG-METHYL-L-ARGININE MONOACETATE SALT
NG-Monomethyl-L-arginine acetate salt
L-NG-MONOMETHYLARGININE, ACETATE SALT
N-GAMMA-MONOMETHYL-L-ARGININE ACETATE
NG-Monomethyl-L-arginine monoacetate,99%
NG-MONOMETHYL-L-ARGININE, MONOACETATE SALT
N5-[METHYLAMIDINO]-L-ORNITHINE ACETATE SALT
NG-Monomethyl-L-arginine Acetate
L-NG-Monomethylarginine, Acetate Salt (L-NMMA)
NG-Methyl-L-arginine acetate salt >=95% (HPLC)
N5-[Imino(methylamino)methyl]-L-ornithine Acetate
N5-[IMINO(METHYLAMINO)METHYL]-L-ORNITHINE, MONOACETATE
L-NMMA, NG-Monomethyl-L-arginine acetate salt, Nω-Methyl-L-arginine acetate salt, N5-(Methylamidino)-L-ornithine acetate salt | [Molecular Formula]
C9H20N4O4 | [MDL Number]
MFCD00069311 | [MOL File]
53308-83-1.mol | [Molecular Weight]
248.28 |
| Chemical Properties | Back Directory | [Appearance]
White Crystalline Powder | [Melting point ]
180-190 °C
| [alpha ]
D22 +9.5° (c = 0.10 in water) | [Boiling point ]
391.35°C (rough estimate) | [density ]
1.2162 (rough estimate) | [refractive index ]
1.6300 (estimate) | [storage temp. ]
2-8°C
| [solubility ]
H2O: 1 mg/mL, clear, colorless
| [form ]
Powder | [color ]
White to Off-white | [Water Solubility ]
Soluble in water (50 mM) | [BRN ]
6674255 | [Stability:]
Store at - 5°C; Desiccate Recommended | [InChI]
1S/C7H16N4O2.C2H4O2/c1-10-7(9)11-4-2-3-5(8)6(12)13;1-2(3)4/h5H,2-4,8H2,1H3,(H,12,13)(H3,9,10,11);1H3,(H,3,4)/t5-;/m0./s1 | [InChIKey]
IKPNWIGTWUZCKM-JEDNCBNOSA-N | [SMILES]
CC(O)=O.CNC(=N)NCCC[C@H](N)C(O)=O |
| Hazard Information | Back Directory | [Chemical Properties]
White Crystalline Powder | [Uses]
A potent inhibitor of NO synthase of adrenal glands, brain, and vascular endothelial cells | [Uses]
Reagent to inhibit nitric oxide production in biological systems. | [Biological Activity]
Competitive, irreversible inhibitor of all three NOS isoforms. | [Description]
L-NMMA is the archetypal competitive NOS inhibitor to which other inhibitors are often compared.1 It is a relatively non-selective inhibitor of all NOS isoforms. The Ki values for nNOS (rat), eNOS (human), and iNOS (mouse) are approximately 0.18, 0.4, and 6 μM, respectively.2,3 | [Biochem/physiol Actions]
NG-Methyl-L-arginine is an inhibitor of nitric oxide synthase in neurons, endothelial cells, and macrophages. It inhibits endothelium-derived relaxing factor and promotes contraction in pulmonary artery and vein. It stereo selectively inhibits the generation of nitric oxide (NO) from arginine. It promotes epinephrine and glucose levels, contributing to hyperglycemia in central nervous system. | [storage]
Store at -20°C | [References]
[1] O W GRIFFITH R G K. Nitric oxide synthase inhibitors: amino acids.[J]. Methods in enzymology, 1996, 268: 375-392. DOI: 10.1016/s0076-6879(96)68040-9
[2] C FREY. L-thiocitrulline. A stereospecific, heme-binding inhibitor of nitric-oxide synthases.[J]. The Journal of Biological Chemistry, 1994, 269 42: 26083-26091.
[3] GARVEY E.P. Purification and Characterization of the Constitutive Nitric-Oxide Synthase from Human Placenta[J]. Archives of biochemistry and biophysics, 1994, 311 2: Pages 235-241. DOI: 10.1006/abbi.1994.1232 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|