| Identification | Back Directory | [Name]
C10 bisphosphonate | [CAS]
15049-93-1 | [Synonyms]
C10 bisphosphonate
1-Aminodecylidene bis-Phosphonic Acid
Phosphonic acid, P,P'-(1-iminodecylidene)bis- | [Molecular Formula]
C10H25NO6P2 | [Molecular Weight]
317.26 |
| Chemical Properties | Back Directory | [Boiling point ]
537.8±60.0 °C(Predicted) | [density ]
1.346±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
A crystalline solid | [pka]
-0.58±0.10(Predicted) |
| Hazard Information | Back Directory | [Description]
1-Aminodecylidene bis-phosphonic acid is a potent inhibitor of acid sphingomyelinase (IC50 = 20 nM). It is selective for acid sphingomyelinase over neutral sphingomyelinase (IC50 = >100 μM). 1-Aminodecylidene bis-phosphonic acid completely inhibits apoptosis induced by dexamethasone in HepG2 cells. | [Uses]
C10 Bisphosphonate is an inhibitor for acid sphingomyelinase. C10 Bisphosphonate is promising for research of inflammatory lung diseases, cystic fibrosis and atherosclerosis[1]. | [References]
[1] Novgorodov SA, et al. Acid sphingomyelinase promotes mitochondrial dysfunction due to glutamate-induced regulated necrosis. J Lipid Res. 2018 Feb;59(2):312-329. DOI:10.1194/jlr.M080374 |
|
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
| Company Name: |
Creative Enzymes
|
| Tel: |
1-516-855-7709 |
| Website: |
www.creative-enzymes.com |
|