| Identification | Back Directory | [Name]
1H-Imidazole, 5-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-, hydrochloride (1:1) | [CAS]
150586-72-4 | [Synonyms]
MPV1730
MPV-1730
MPV 1730
Fipamezole HCl
1H-Imidazole, 5-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-, hydrochloride (1:1) | [Molecular Formula]
C14H16ClFN2 | [MOL File]
150586-72-4.mol | [Molecular Weight]
266.74 |
| Hazard Information | Back Directory | [Uses]
Fipamezole hydrochloride is a potent and orally active α2-adrenergic receptor antagonist with Ki values of 9.2 nM, 17 nM, and 55 nM for human α2A, α2B, and α2C, receptors, respectively. Fipamezole hydrochloride is an anti-dyskinetic agent, and can be used for the study of Parkinson's disease[1]. | [References]
[1] Juha-Matti Savola, et al. Fipamezole (JP-1730) is a potent alpha2 adrenergic receptor antagonist that reduces levodopa-induced dyskinesia in the MPTP-lesioned primate model of Parkinson's disease. Mov Disord. 2003 Aug;18(8):872-83. DOI:10.1002/mds.10464 |
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