| Identification | Back Directory | [Name]
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride | [CAS]
72795-01-8 | [Synonyms]
CS-769
CI 118551 Hydrochloride
ICI 118,551 hydrochloride, >=98%
(2R,3R)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride (1:1)
(±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride | [Molecular Formula]
C17H28ClNO2 | [MOL File]
72795-01-8.mol | [Molecular Weight]
313.863 |
| Chemical Properties | Back Directory | [storage temp. ]
desiccated | [solubility ]
DMSO : 25 mg/mL (79.65 mM; Need ultrasonic)H2O : 12.5 mg/mL (39.83 mM; Need ultrasonic) | [form ]
powder | [color ]
white | [Water Solubility ]
H2O: >10mg/mL |
| Hazard Information | Back Directory | [Description]
ICI 118551 is a potent, selective antagonist of the β2-adrenergic receptor (Ki = 0.7 nM for the β2receptor, compared with 49.5 and 611 nM for β1 and β3 receptors, respectively). It is active in vivo and is often used to evaluate the actions of adrenergic receptor agonists. | [Uses]
The (R,R)-enantiomer | [Biochem/physiol Actions]
ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state. | [in vivo]
Zenidolol (ICI-118551; 0.2 mg/kg) hydrochloride injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure[2]. | [IC 50]
β adrenergic receptor | [storage]
Store at -20°C | [References]
[1] N M DEIGHTON. Characterization of the beta adrenoceptor subtype(s) mediating the positive inotropic effects of epinine, dopamine, dobutamine, denopamine and xamoterol in isolated human right atrium.[J]. Journal of Pharmacology and Experimental Therapeutics, 1992, 262 2: 532-538.
[2] NANCY J. ROTHWELL Deepak K S Michael J Stock. Changes in tissue blood flow and β-receptor density of skeletal muscle in rats treated with the β2-adrenoceptor agonist clenbuterol[J]. British Journal of Pharmacology, 1987, 90 3: 601-607. DOI: 10.1111/j.1476-5381.1987.tb11211.x
[3] IL-MAN KIM. Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2008: 14555-14560. DOI: 10.1073/pnas.0804745105 |
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