| Identification | Back Directory | [Name]
S-8921 | [CAS]
151165-96-7 | [Synonyms]
S-8921
2-Naphthalenecarboxylic acid, 1-(3,4-dimethoxyphenyl)-3-(3-ethyl-1-oxopentyl)-4-hydroxy-6,7,8-trimethoxy-, methyl ester | [Molecular Formula]
C30H36O9 | [MDL Number]
MFCD31812268 | [MOL File]
151165-96-7.mol | [Molecular Weight]
540.6 |
| Chemical Properties | Back Directory | [Boiling point ]
664.9±55.0 °C(Predicted) | [density ]
1.176±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
7.00±0.50(Predicted) |
| Hazard Information | Back Directory | [Uses]
S-8921 is an ileal Na+/bile acid cotransporter (IBAT) inhibitor. | [in vivo]
Seven-day treatment with S-8921 causes a dramatic decrease of serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921[1]. S-8921 treatment for 1 to 2 weeks causes a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective[2]. | [storage]
Store at -20°C | [References]
[1] Hara S, et al. S-8921, an ileal Na+/bile acid cotransporter inhibitor decreases serum cholesterol in hamsters. Life Sci. 1997;60(24):PL 365-70. DOI:10.1016/s0024-3205(97)00242-7
[2] Higaki J, et al. Inhibition of ileal Na+/bile acid cotransporter by S-8921 reduces serum cholesterol and prevents atherosclerosis in rabbits. Arterioscler Thromb Vasc Biol. 1998 Aug;18(8):1304-11. DOI:10.1161/01.atv.18.8.1304 |
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