| Identification | Back Directory | [Name]
XEN445 | [CAS]
1515856-92-4 | [Synonyms]
XEN445
CS-1251
XEN 445, >=98%
XEN 445; XEN-445
XEN445 >=98% (HPLC)
2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid
(S)-2-(3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl)-5-(trifluoromethyl)benzoic acid
2-[(3S)-3-(pyridin-2-ylmethoxy)pyrrolidin-1-yl]-5-(trifluoromethyl)benzoic acid
Benzoic acid, 2-[(3S)-3-(2-pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)-
(S)-2-(3-(PYRIDIN-2-YLMETHOXY)PYRROLIDIN-1-YL)-5-(TRIFLUOROMETHYL)BENZOIC ACID. HCL
2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid XEN445
XEN445 2-[(3S)-3-(2-Pyridinylmethoxy)-1-pyrrolidinyl]-5-(trifluoromethyl)benzoic acid | [Molecular Formula]
C18H17F3N2O3 | [MDL Number]
MFCD28166367 | [MOL File]
1515856-92-4.mol | [Molecular Weight]
366.33 |
| Chemical Properties | Back Directory | [Boiling point ]
490.9±45.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 25 mg/ml; Ethanol: 14 mg/ml | [form ]
A crystalline solid | [pka]
3.35±0.36(Predicted) | [color ]
Light brown to brown |
| Hazard Information | Back Directory | [Description]
Endothelial lipase, a member of the triglyceride lipase gene family expressed in endothelial cells, prefers phospholipid-enriched high-density lipoprotein (HDL) over triglyceride as a substrate. XEN445 is an endothelial lipase inhibitor (IC50 = 237 nM) that demonstrates selectivity for endothelial lipase compared to lipoprotein and hepatic lipases (IC50s = 20 and 9.5 μM, respectivley). An oral dose of 30 mg/kg XEN445 is reported to increase HDL cholesterol concentrations by 16% after three days and by 30% after nine days dosing in wild-type mice. | [Uses]
XEN445 is a potent and selective endothelial lipase inhibitor. | [storage]
Store at -20°C | [References]
[1] SHAOYI SUN . Discovery of XEN445: A potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice[J]. Bioorganic & Medicinal Chemistry, 2013, 21 24: Pages 7724-7734. DOI: 10.1016/j.bmc.2013.10.023 |
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| Company Name: |
China Langchem Inc.
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| Tel: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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