| Identification | Back Directory | [Name]
Aphadilactone C | [CAS]
1522004-70-1 | [Synonyms]
Aphadilactone C
3(2H)-Benzofuranone, 4-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-4,7-bis[(4E)-5-[(2S)-3,6-dihydro-4-methyl-6-oxo-2H-pyran-2-yl]-4-methyl-4-penten-1-yl]-4,5,6,7-tetrahydro-2,2-dimethyl-, (4S,7S)- | [Molecular Formula]
C40H52O8 | [MDL Number]
MFCD28385954 | [MOL File]
1522004-70-1.mol | [Molecular Weight]
660.84 |
| Hazard Information | Back Directory | [Uses]
Aphadilactone C is a potent and selective DGAT-1 inhibitor with an IC50 of 0.46 μM. Aphadilactone C shows significant antimalarial activities with an IC50 value of 170 nM[1]. | [References]
[1] Jia Liu, et al. Aphadilactones A-D, four diterpenoid dimers with DGAT inhibitory and antimalarial activities from a Meliaceae plant. J Org Chem. 2014 Jan 17;79(2):599-607. DOI:10.1021/jo402340h |
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